EP 1226168 A1 20020731 - LIGAND ACTIVATED TRANSCRIPTIONAL REGULATOR PROTEINS
Title (en)
LIGAND ACTIVATED TRANSCRIPTIONAL REGULATOR PROTEINS
Title (de)
LIGAND-AKTIVIERTE TRANSKRIPTIONSREGULATORISCHE PROTEINE
Title (fr)
PROTEINES DE REGULATEUR DE TRANSCRIPTION ACTIVEES PAR UN LIGAND
Publication
Application
Priority
- EP 0010430 W 20001023
- US 43304299 A 19991025
- US 58662500 A 20000602
Abstract (en)
[origin: WO0130843A1] Fusion proteins for use as ligand-dependent transcriptional are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also can include a transcription regulating domain. The nucleotide binding domain is a zinc-finger peptide that binds to a targeted contiguous nucleotide sequence of from 3 to 18 nucleotides are provided. The fusion proteins are used for gene therapy. Also provided are polynucleotides encoding the fusion proteins, expression vectors, and transfected cells.
IPC 1-7
C07K 14/47; C07K 14/72; C12N 15/62; C12N 15/86; A61K 38/17; C07K 14/705
IPC 8 full level
C12N 15/09 (2006.01); A61K 9/127 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 14/72 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 5/10 (2006.01); C12N 15/63 (2006.01)
CPC (source: EP US)
A61P 17/00 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/4702 (2013.01 - EP US); C07K 14/70567 (2013.01 - EP US); C07K 14/721 (2013.01 - EP US); C12N 15/63 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US)
Citation (search report)
See references of WO 0130843A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0130843 A1 20010503; WO 0130843 A9 20020919; AU 1143801 A 20010508; AU 775988 B2 20040819; CA 2388535 A1 20010503; EP 1226168 A1 20020731; IL 149142 A0 20021110; IL 149142 A 20100531; JP 2003512827 A 20030408; JP 2009273463 A 20091126; NZ 518218 A 20040430; US 2003186841 A1 20031002; US 2008318839 A1 20081225; US 7329728 B1 20080212; US 7442784 B2 20081028
DOCDB simple family (application)
EP 0010430 W 20001023; AU 1143801 A 20001023; CA 2388535 A 20001023; EP 00972849 A 20001023; IL 14914200 A 20001023; IL 14914202 A 20020415; JP 2001533840 A 20001023; JP 2009147520 A 20090622; NZ 51821800 A 20001023; US 22032808 A 20080722; US 42293403 A 20030423; US 58662500 A 20000602