EP 1226280 A2 20020731 - GENETIC SEQUENCES ASSOCIATED WITH NEURAL CELL PROLIFERATION AND DISEASE
Title (en)
GENETIC SEQUENCES ASSOCIATED WITH NEURAL CELL PROLIFERATION AND DISEASE
Title (de)
GENETICHE SEQUENZEN, WELCHE MIT NEURALER ZELLPROLIFERATION UND ERKRANKUNGEN ASSOZIIERT SIND
Title (fr)
SEQUENCES GENETIQUES ASSOCIEES A LA PROLIFERATION ET AUX PATHOLOGIES DES CELLULES NEURONALES
Publication
Application
Priority
- US 0041515 W 20001025
- US 16133799 P 19991025
- US 22763900 P 20000824
Abstract (en)
[origin: WO0130973A2] Applying large-scale DNA microarray techniques, the developmental molecular programs of the hippocampus, a cortical structure critical for learning and memory has been anlyzed. Over 30,000 genes and EST sequences were screened, including an estimated 30-40% of total genes in the mouse genome. As a result, the present invention identifies 4,390 genes that showed dynamic changes during hippocampal development. Moreover, using genecluster analysis, these genes were grouped into 16 distinct clusters with striking patterns that correlate with major developmental hallmarks. The covariance analysis strategy was then applied. This enabled the identification of a group of genes whose expression may underlie the phenotypic changes in the hippocampus.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); C07K 14/71 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
C07K 14/47 (2013.01); C07K 14/71 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/136 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0130973 A2 20010503; WO 0130973 A3 20010920; AU 2470101 A 20010508; CA 2389834 A1 20010503; EP 1226280 A2 20020731; EP 1226280 A4 20031015
DOCDB simple family (application)
US 0041515 W 20001025; AU 2470101 A 20001025; CA 2389834 A 20001025; EP 00988496 A 20001025