EP 1227883 A1 20020807 - CATALYST FOR ASYMMETRIC TRANSFER HYDROGENATION
Title (en)
CATALYST FOR ASYMMETRIC TRANSFER HYDROGENATION
Title (de)
KATALYSATOR FÜR ASYMMETRISCHE TRANFERHYDRIERUNG
Title (fr)
CATALYSEUR POUR HYDROGENATION PAR TRANSFERT ASYMETRIQUE
Publication
Application
Priority
- NL 0000701 W 20000929
- NL 1013183 A 19990930
Abstract (en)
[origin: WO0123088A1] The invention relates to a catalyst for asymmetrical transfer hydrogenation on the basis of a transition metal compound and a nitrogen-containing enantiomerically enriched ligand. The invention also relates to various processes for the preparation of enantiomerically enriched compounds using the catalyst according to the invention. In the catalyst according to the invention the transition metal is iridium, ruthenium, rhodium or cobalt and the enantiomerically enriched ligand contains sulphur in the form of a thioether or a sulphoxide, the sulphur being bound to the nitrogen via two or more carbon atoms. Surprisingly, it has been found that with the catalyst according to the invention a high conversion in a good enantiomeric excess of the enantiomerically enriched compound can be obtained. It has been found, in addition, that the catalyst with iridium as metal is also very stable in formic acid, so that formic acid can be used as the hydrogen donor, making the reaction irreversible and thereby allowing it to run to completion so that higher substrate concentrations can be used.
IPC 1-7
B01J 31/22; C07B 53/00; C07C 323/58; C07C 323/25; C07C 317/28
IPC 8 full level
B01J 31/22 (2006.01); C07B 53/00 (2006.01); C07B 57/00 (2006.01); C07B 61/00 (2006.01); C07C 29/143 (2006.01); C07C 33/22 (2006.01); C07C 33/34 (2006.01); C07C 317/28 (2006.01); C07C 323/29 (2006.01); C07C 323/58 (2006.01)
CPC (source: EP)
B01J 31/1805 (2013.01); B01J 31/226 (2013.01); C07B 53/00 (2013.01); C07B 57/00 (2013.01); C07C 29/143 (2013.01); C07C 317/28 (2013.01); C07C 323/29 (2013.01); C07C 323/58 (2013.01); B01J 31/2208 (2013.01); B01J 2231/643 (2013.01); B01J 2531/821 (2013.01); B01J 2531/822 (2013.01); B01J 2531/827 (2013.01); B01J 2531/845 (2013.01); C07B 2200/07 (2013.01); C07C 2601/14 (2017.04)
Citation (search report)
See references of WO 0123088A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0123088 A1 20010405; AU 7972100 A 20010430; EP 1227883 A1 20020807; JP 2003510180 A 20030318; NL 1013183 C2 20010402
DOCDB simple family (application)
NL 0000701 W 20000929; AU 7972100 A 20000929; EP 00970322 A 20000929; JP 2001526290 A 20000929; NL 1013183 A 19990930