EP 1231913 A2 20020821 - TREATMENT OF CYCLOOXYGENASE-2 MEDIATED DISORDERS USING CONJUGATED FATTY ACID COMPOUNDS
Title (en)
TREATMENT OF CYCLOOXYGENASE-2 MEDIATED DISORDERS USING CONJUGATED FATTY ACID COMPOUNDS
Title (de)
BEHANDLUNG VON CYCLOOXYGENASE-2 BEDINGTEN ERKRANKUNGEN UNTER VERWENDUNG VON CONJUGIERTEN FETTSÄUREVERBINDUNGEN
Title (fr)
TRAITEMENT DE TROUBLES INDUITS PAR UNE CYCLOXYGENASE-2 AU MOYEN DE COMPOSES A BASE D'ACIDES GRAS CONJUGUES
Publication
Application
Priority
- US 0040138 W 20000607
- US 14303199 P 19990709
Abstract (en)
[origin: WO0103688A2] This invention is directed to a process for the prevention or treatment of inflammation or other cyclooxygenase-2 mediated disorders. This process comprises administering a conjugated fatty acid to an organism in an amount effective to prevent or treat the cyclooxygenase-2 mediated disorder by inhibiting cyclooxygenase -2. In one embodiment, the process comprises administering a fatty acid compound having formula (I) or a pharmaceutically acceptable salt thereof, wherein R<1> is hydrogen, hydrocarbyl, or substituted hydrocarbyl; m is from 6 to 11; and the sum of n and m is from 13 to 16. In another embodiment, the process comprises administering a fatty acid compound having formula (VI) or a pharmaceutically acceptable salt thereof, wherein R<6> is hydrogen, hydrocarbyl, or substituted hydrocarbyl; R<7> is -OH, -SO3H, -SH, -NH2, -PO3H2, or halogen; v is from 7 to 11; and the sum of v and w is from 11 to 15. This invention is also directed to a process for preparing a fatty acid compound. The process comprises combining a ylide with an aldehyde.
IPC 1-7
A61K 31/201; A61P 3/00; A61P 11/06; A61P 17/00; A61P 19/02; A61P 25/28; A61P 27/00; A61P 29/00; A61P 35/00; A61P 37/08; A61P 43/00
IPC 8 full level
A61K 38/43 (2006.01); A61K 31/201 (2006.01); A61K 31/205 (2006.01); A61K 31/231 (2006.01); A61K 31/28 (2006.01); A61K 31/295 (2006.01); A61K 31/30 (2006.01); A61K 31/315 (2006.01); A61K 38/44 (2006.01); A61K 45/06 (2006.01); A61P 1/02 (2006.01); A61P 1/04 (2006.01); A61P 3/00 (2006.01); A61P 3/10 (2006.01); A61P 5/14 (2006.01); A61P 7/06 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 15/06 (2006.01); A61P 17/00 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 19/08 (2006.01); A61P 21/00 (2006.01); A61P 21/04 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/28 (2006.01); A61P 27/00 (2006.01); A61P 27/02 (2006.01); A61P 27/16 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 37/02 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07C 51/353 (2006.01); C07C 57/03 (2006.01); C07C 67/343 (2006.01); C07C 69/587 (2006.01)
CPC (source: EP)
A61K 31/201 (2013.01); A61K 31/205 (2013.01); A61K 31/231 (2013.01); A61K 31/28 (2013.01); A61K 31/295 (2013.01); A61K 31/30 (2013.01); A61K 31/315 (2013.01); A61K 31/661 (2013.01); A61K 38/44 (2013.01); A61K 45/06 (2013.01); A61P 1/02 (2017.12); A61P 1/04 (2017.12); A61P 3/00 (2017.12); A61P 3/10 (2017.12); A61P 5/14 (2017.12); A61P 7/06 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 15/06 (2017.12); A61P 17/00 (2017.12); A61P 17/02 (2017.12); A61P 17/06 (2017.12); A61P 19/02 (2017.12); A61P 19/08 (2017.12); A61P 21/00 (2017.12); A61P 21/04 (2017.12); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/06 (2017.12); A61P 25/28 (2017.12); A61P 27/00 (2017.12); A61P 27/02 (2017.12); A61P 27/16 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 37/02 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C12Y 113/11 (2013.01)
Citation (search report)
See references of WO 0103688A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0103688 A2 20010118; WO 0103688 A3 20020620; AU 6402700 A 20010130; EP 1231913 A2 20020821; JP 2003506324 A 20030218
DOCDB simple family (application)
US 0040138 W 20000607; AU 6402700 A 20000607; EP 00951029 A 20000607; JP 2001508969 A 20000607