EP 1235568 A2 20020904 - DEPLETION OF CELLULAR COENZYME-A LEVELS AS A MEANS TO SELECTIVELY KILL CANCER CELLS
Title (en)
DEPLETION OF CELLULAR COENZYME-A LEVELS AS A MEANS TO SELECTIVELY KILL CANCER CELLS
Title (de)
VERMINDERUNG VON INTRAZELLULÄREN COENZYM-A SPIEGELN ALS MITTEL ZUR SELEKTIVEN ABTÖTUNG VON KREBSZELLEN
Title (fr)
BAISSE DES NIVEAUX DE COENZYME A CELLULAIRE, UTILISEE EN TANT QUE MOYEN D'ELIMINER DE FA ON SELECTIVE DES CELLULES CANCEREUSES
Publication
Application
Priority
- US 0031068 W 20001113
- US 16474999 P 19991112
Abstract (en)
[origin: WO0134202A2] The invention describes a method to inhibit growth or kill cancer cells by acute depletion of free cellular Coenzyme A (CoA). This invention encompasses: any method to selectively decrease CoA in cancer cells by increasing the utilization of CoA and/or reducing its synthesis. As demonstrated herein, depletion of free CoA may be accomplished by inhibiting fatty acid synthase (FAS). This invention also includes depletion of free cellular Coenzyme A by interventions in addition to or alternative to FAS inhibition.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/34 (2006.01); A61K 31/365 (2006.01); A61K 45/00 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP KR)
A61K 31/00 (2013.01 - EP); A61K 31/34 (2013.01 - EP); A61K 31/365 (2013.01 - EP); A61K 45/00 (2013.01 - KR); A61K 45/06 (2013.01 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); G01N 33/5017 (2013.01 - EP)
Citation (search report)
See references of WO 0134202A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0134202 A2 20010517; WO 0134202 A3 20020418; AU 1485401 A 20010606; CA 2390501 A1 20010517; EP 1235568 A2 20020904; JP 2003516938 A 20030520; KR 20020060737 A 20020718
DOCDB simple family (application)
US 0031068 W 20001113; AU 1485401 A 20001113; CA 2390501 A 20001113; EP 00977179 A 20001113; JP 2001536199 A 20001113; KR 20027006104 A 20020511