Global Patent Index - EP 1235568 A2

EP 1235568 A2 2002-09-04 - DEPLETION OF CELLULAR COENZYME-A LEVELS AS A MEANS TO SELECTIVELY KILL CANCER CELLS

Title (en)

DEPLETION OF CELLULAR COENZYME-A LEVELS AS A MEANS TO SELECTIVELY KILL CANCER CELLS

Title (de)

VERMINDERUNG VON INTRAZELLULÄREN COENZYM-A SPIEGELN ALS MITTEL ZUR SELEKTIVEN ABTÖTUNG VON KREBSZELLEN

Title (fr)

BAISSE DES NIVEAUX DE COENZYME A CELLULAIRE, UTILISEE EN TANT QUE MOYEN D'ELIMINER DE FA ON SELECTIVE DES CELLULES CANCEREUSES

Publication

EP 1235568 A2 (EN)

Application

EP 00977179 A

Priority

  • US 0031068 W
  • US 16474999 P

Abstract (en)

[origin: WO0134202A2] The invention describes a method to inhibit growth or kill cancer cells by acute depletion of free cellular Coenzyme A (CoA). This invention encompasses: any method to selectively decrease CoA in cancer cells by increasing the utilization of CoA and/or reducing its synthesis. As demonstrated herein, depletion of free CoA may be accomplished by inhibiting fatty acid synthase (FAS). This invention also includes depletion of free cellular Coenzyme A by interventions in addition to or alternative to FAS inhibition.

IPC 1-7 (main, further and additional classification)

A61K 31/365

IPC 8 full level (invention and additional information)

A61K 31/00 (2006.01); A61K 31/34 (2006.01); A61K 31/365 (2006.01); A61K 45/00 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)

CPC (invention and additional information)

G01N 33/5017 (2013.01); A61K 31/00 (2013.01); A61K 31/34 (2013.01); A61K 31/365 (2013.01); A61K 45/06 (2013.01)

Citation (search report)

See references of WO 0134202A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0134202 A2 20010517; WO 0134202 A3 20020418; AU 1485401 A 20010606; CA 2390501 A1 20010517; EP 1235568 A2 20020904; JP 2003516938 A 20030520

INPADOC legal status


2004-07-21 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20040115

2003-08-20 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030704

2002-09-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020515

2002-09-04 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-04 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI