Global Patent Index - EP 1235793 A2

EP 1235793 A2 2002-09-04 - VLA-4 INTEGRIN ANTAGONISTS

Title (en)

VLA-4 INTEGRIN ANTAGONISTS

Title (de)

VLA-4 INTEGRIN-ANTAGONISTEN

Title (fr)

ANTAGONISTES DE L'INTEGRINE VLA-4

Publication

EP 1235793 A2 (EN)

Application

EP 00990650 A

Priority

  • EP 0012226 W
  • US 45567099 A

Abstract (en)

[origin: WO0142192A2] Compounds of formula (I) wherein Ar is carbocyclic or heterocyclic aryl, or biaryl; Q is O, S or N-CN; X is arylene; V is NH, O, NHOH, CH2 or a direct bond; W is NH, O, NHOH, CH2 or a direct bond; Alk is C2-C7-alkylene or C2-C7-alkylene interrupted by O, S, SO, SO2 or NR3; Y is amino, acylamino, mono- or di- (lower alkyl, aryl or aralkyl)-amino, pyrrolidino, perhydroazepino or a group of the formula (II) in which M1 is N; and M2 is CH2, O, NR3, S, SO or SO2; R1, R2 and R3 are independently hydrogen, lower alkyl, lower alkenyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or aryl-lower alkenyl; Z is lower alkylene or lower alkylene substituted by one or more of lower alkyl, lower alkenyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or aryl-lower alkenyl; or Z is lower alkylene interrupted by O, S, SO, SO2 or NR3; pharmaceutically acceptable esters and amides thereof; and pharmaceutically acceptable salts thereof, which are useful as VLA-4 integrin antagonists.

IPC 1-7 (main, further and additional classification)

C07C 275/38; A61K 31/17; A61K 31/5375; A61P 27/02; C07D 295/13

IPC 8 full level (invention and additional information)

C07D 295/12 (2006.01); A61K 31/197 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61P 11/00 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C07C 273/18 (2006.01); C07C 275/42 (2006.01); C07C 279/28 (2006.01); C07D 295/13 (2006.01); C07D 295/18 (2006.01); C07D 295/185 (2006.01)

CPC (invention and additional information)

C07D 295/185 (2013.01); A61K 31/5375 (2013.01); C07C 275/42 (2013.01); C07C 279/28 (2013.01); C07D 295/13 (2013.01)

Citation (search report)

See references of WO 0142192A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0142192 A2 20010614; WO 0142192 A3 20020110; AU 3006401 A 20010618; CA 2388686 A1 20010614; EP 1235793 A2 20020904; JP 2003516380 A 20030513

INPADOC legal status


2004-01-07 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030701

2002-09-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020412

2002-09-04 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-04 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL;LT;LV;MK;RO;SI