EP 1235793 A2 20020904 - VLA-4 INTEGRIN ANTAGONISTS
Title (en)
VLA-4 INTEGRIN ANTAGONISTS
Title (de)
VLA-4 INTEGRIN-ANTAGONISTEN
Title (fr)
ANTAGONISTES DE L'INTEGRINE VLA-4
Publication
Application
Priority
- EP 0012226 W 20001205
- US 45567099 A 19991207
Abstract (en)
[origin: WO0142192A2] Compounds of formula (I) wherein Ar is carbocyclic or heterocyclic aryl, or biaryl; Q is O, S or N-CN; X is arylene; V is NH, O, NHOH, CH2 or a direct bond; W is NH, O, NHOH, CH2 or a direct bond; Alk is C2-C7-alkylene or C2-C7-alkylene interrupted by O, S, SO, SO2 or NR3; Y is amino, acylamino, mono- or di- (lower alkyl, aryl or aralkyl)-amino, pyrrolidino, perhydroazepino or a group of the formula (II) in which M1 is N; and M2 is CH2, O, NR3, S, SO or SO2; R1, R2 and R3 are independently hydrogen, lower alkyl, lower alkenyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or aryl-lower alkenyl; Z is lower alkylene or lower alkylene substituted by one or more of lower alkyl, lower alkenyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or aryl-lower alkenyl; or Z is lower alkylene interrupted by O, S, SO, SO2 or NR3; pharmaceutically acceptable esters and amides thereof; and pharmaceutically acceptable salts thereof, which are useful as VLA-4 integrin antagonists.
IPC 1-7
C07C 275/38; C07D 295/13; A61K 31/5375; A61K 31/17; A61P 27/02
IPC 8 full level
A61K 31/197 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61P 11/00 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C07C 273/18 (2006.01); C07C 275/42 (2006.01); C07C 279/28 (2006.01); C07D 295/12 (2006.01); C07D 295/13 (2006.01); C07D 295/18 (2006.01); C07D 295/185 (2006.01)
CPC (source: EP)
A61K 31/5375 (2013.01); A61P 11/00 (2017.12); A61P 19/02 (2017.12); A61P 27/02 (2017.12); A61P 37/06 (2017.12); A61P 43/00 (2017.12); C07C 275/42 (2013.01); C07C 279/28 (2013.01); C07D 295/13 (2013.01); C07D 295/185 (2013.01)
Citation (search report)
See references of WO 0142192A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0142192 A2 20010614; WO 0142192 A3 20020110; AU 3006401 A 20010618; CA 2388686 A1 20010614; EP 1235793 A2 20020904; JP 2003516380 A 20030513
DOCDB simple family (application)
EP 0012226 W 20001205; AU 3006401 A 20001205; CA 2388686 A 20001205; EP 00990650 A 20001205; JP 2001543494 A 20001205