EP 1235808 A2 20020904 - TRICYCLIC ANALGESICS
Title (en)
TRICYCLIC ANALGESICS
Title (de)
TRIZYCLISCHE ANALGETIKA
Title (fr)
ANALGESIQUES TRICYCLIQUES
Publication
Application
Priority
- EP 0005783 W 20000607
- US 13786899 P 19990607
Abstract (en)
[origin: WO0075116A2] A tricyclic compound of Formula (I): wherein: R<1> is hydrogen or hydroxy; R<2> is hydrogen or hydroxy; or R<1> and R<2> together are oxygen; A is a bond, CH2, CH CH3, CH2 CH2 or C(CH3)2; R<3> and R<4> are the same or different and are hydrogen, halo, C1-C6 alkyl, C1-C4 alkoxy, trifluoromethyl, NO2, COR<6>, COOR<6> or NR<6>R<7>, wherein R<6> and R<7> are the same or different and are hydrogen, C1-C6 alkyl or benzyl; R<5> is hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, (O=C)-C1-6 alkyl, (O=C)-C2-6 alkenyl, (O=C)-C3-6 cycloalkyl, wherein said alkyl, alkenyl and cycloalkyl groups can be substituted by 1, 2 or 3 groups selected from halo, C3-C6 cycloalkyl, phenyl or substituted phenyl, and salts thereof, are particularly useful for treating, among other indications, neuropathic pain and other CNS disorders.
IPC 1-7
IPC 8 full level
A61K 31/438 (2006.01); A61P 25/00 (2006.01); A61P 29/02 (2006.01); C07D 221/00 (2006.01); C07D 221/20 (2006.01)
CPC (source: EP KR)
A61K 31/438 (2013.01 - KR); A61P 25/00 (2018.01 - EP); A61P 29/02 (2018.01 - EP); C07D 221/20 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0075116 A2 20001214; WO 0075116 A3 20020704; AP 2001002356 A0 20011231; AU 6428400 A 20001228; BG 106162 A 20020531; BR 0011427 A 20020326; CA 2376076 A1 20001214; CN 1635998 A 20050706; EA 200101117 A1 20020627; EP 1235808 A2 20020904; HR P20010913 A2 20030430; HU P0203317 A2 20030228; IL 146755 A0 20020725; IS 6175 A 20011123; JP 2003513006 A 20030408; KR 20020010923 A 20020206; MA 26795 A1 20041220; MX PA01012694 A 20031015; NO 20015966 D0 20011206; NO 20015966 L 20011206; PL 357340 A1 20040726; SK 17512001 A3 20021106; TR 200103531 T2 20020621
DOCDB simple family (application)
EP 0005783 W 20000607; AP 2001002356 A 20000607; AU 6428400 A 20000607; BG 10616201 A 20011130; BR 0011427 A 20000607; CA 2376076 A 20000607; CN 00808642 A 20000607; EA 200101117 A 20000607; EP 00951290 A 20000607; HR P20010913 A 20011207; HU P0203317 A 20000607; IL 14675500 A 20000607; IS 6175 A 20011123; JP 2001501597 A 20000607; KR 20017015730 A 20011206; MA 26431 A 20011130; MX PA01012694 A 20000607; NO 20015966 A 20011206; PL 35734000 A 20000607; SK 17512001 A 20000607; TR 200103531 T 20000607