Global Patent Index - EP 1235815 A1

EP 1235815 A1 2002-09-04 - QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES

Title (en)

QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES

Title (de)

CHINAZOLINE UND IHRE VERWENDUNG ALS CYCLIN-DEPENDENT KINASE ENZYM- INHIBITOREN

Title (fr)

QUINAZOLINES ET LEUR UTILISATION DANS L'INHIBITION DES ENZYMES KINASE DEPENDANT DE LA CYCLINE

Publication

EP 1235815 A1 (EN)

Application

EP 00976914 A

Priority

  • US 0030376 W
  • US 16684099 P

Abstract (en)

[origin: WO0138315A1] This invention provides quinazolines that are useful for treating cell proliferative diseases and disorders, such as cardiovascular diseases, infections, cancers, autoimmune diseases, gout, kidney disease, and neurodegenerative diseases and disorders such as Alzheimer's disease. We have now discovered a group of 2-arylamino-quinazolines (I) and (II) that are potent inhibitors of cyclin-dependent kinases (cdks). The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention also provides pharmaceutical formulations comprising at least one of the quinazoline compounds together with a pharmaceutically acceptable carrier, diluent, or excipient therefor. The invention further provides useful intermediates generated during the production of the quinazoline compounds.

IPC 1-7 (main, further and additional classification)

C07D 239/84; A61K 31/517; C07D 239/78; C07D 239/80; C07D 403/12

IPC 8 full level (invention and additional information)

A61K 31/517 (2006.01); A61K 31/5377 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 31/10 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C07D 239/78 (2006.01); C07D 239/80 (2006.01); C07D 239/84 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01)

CPC (invention and additional information)

C07D 401/12 (2013.01); C07D 239/84 (2013.01); C07D 403/12 (2013.01)

Citation (search report)

See references of WO 0138315A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0138315 A1 20010531; AU 1462101 A 20010604; BR 0015718 A 20020723; CA 2386955 A1 20010531; EP 1235815 A1 20020904; JP 2003514901 A 20030422; MX PA02003140 A 20020930

INPADOC legal status


2007-11-28 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20070601

2007-02-21 [RAP1] TRANSFER OF RIGHTS OF AN APPLICATION

- Owner name: WARNER-LAMBERT COMPANY LLC

2005-06-01 [RAP1] TRANSFER OF RIGHTS OF AN APPLICATION

- Owner name: WARNER-LAMBERT COMPANY LLC

2002-09-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020624

2002-09-04 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-04 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI