EP 1235815 A1 20020904 - QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES
Title (en)
QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES
Title (de)
CHINAZOLINE UND IHRE VERWENDUNG ALS CYCLIN-DEPENDENT KINASE ENZYM- INHIBITOREN
Title (fr)
QUINAZOLINES ET LEUR UTILISATION DANS L'INHIBITION DES ENZYMES KINASE DEPENDANT DE LA CYCLINE
Publication
Application
Priority
- US 0030376 W 20001103
- US 16684099 P 19991122
Abstract (en)
[origin: WO0138315A1] This invention provides quinazolines that are useful for treating cell proliferative diseases and disorders, such as cardiovascular diseases, infections, cancers, autoimmune diseases, gout, kidney disease, and neurodegenerative diseases and disorders such as Alzheimer's disease. We have now discovered a group of 2-arylamino-quinazolines (I) and (II) that are potent inhibitors of cyclin-dependent kinases (cdks). The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention also provides pharmaceutical formulations comprising at least one of the quinazoline compounds together with a pharmaceutically acceptable carrier, diluent, or excipient therefor. The invention further provides useful intermediates generated during the production of the quinazoline compounds.
IPC 1-7
C07D 239/84; C07D 403/12; A61K 31/517; C07D 239/78; C07D 239/80
IPC 8 full level
A61K 31/517 (2006.01); A61K 31/5377 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 31/10 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C07D 239/78 (2006.01); C07D 239/80 (2006.01); C07D 239/84 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01)
CPC (source: EP)
A61P 9/10 (2017.12); A61P 13/12 (2017.12); A61P 25/28 (2017.12); A61P 29/00 (2017.12); A61P 31/10 (2017.12); A61P 35/00 (2017.12); A61P 37/04 (2017.12); A61P 37/06 (2017.12); A61P 43/00 (2017.12); C07D 239/84 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01)
Citation (search report)
See references of WO 0138315A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0138315 A1 20010531; AU 1462101 A 20010604; BR 0015718 A 20020723; CA 2386955 A1 20010531; EP 1235815 A1 20020904; JP 2003514901 A 20030422; MX PA02003140 A 20020930
DOCDB simple family (application)
US 0030376 W 20001103; AU 1462101 A 20001103; BR 0015718 A 20001103; CA 2386955 A 20001103; EP 00976914 A 20001103; JP 2001540078 A 20001103; MX PA02003140 A 20001103