EP 1235922 A2 20020904 - EXCIPIENT SYSTEM THAT CONTAINS COATING SUBSTANCES WITH ENZYMATICALLY REMOVABLE SIDE-GROUPS
Title (en)
EXCIPIENT SYSTEM THAT CONTAINS COATING SUBSTANCES WITH ENZYMATICALLY REMOVABLE SIDE-GROUPS
Title (de)
TRÄGERSYSTEME, ENTHALTEND HÜLLSUBSTANZEN MIT ENZYMATISCH ABSPALTBAREN SEITENGRUPPEN
Title (fr)
SYSTEMES PORTEURS COMPORTANT DES SUBSTANCES ENVELOPPANTES AVEC GROUPES LATERAUX POUVANT ETRE SEPARES DE MANIERE ENZYMATIQUE
Publication
Application
Priority
- DE 19956029 A 19991122
- EP 0011055 W 20001109
Abstract (en)
[origin: DE19956029A1] A carrier system for active substances is based on coating a substance with enzymatically cleavable anionic side groups which determine the stability of the system and which, when cleaved, result in collapse of the system and liberation of the active substance. A carrier system is obtained by the admixture of component (b1) with either component (a1) or a complex obtained from component (a1) and component (a2) in a molar ratio of 1:1-0000, with the components being admixed in amounts to provide a finished complex which is preferably neutral or anionic. Component (a1) comprises an active substance (a1) and a binding structure (a1) (which can be part of the active substance) for binding structure (b1) or (a2). Component (a2) comprises a carrier (a2) and a binding structure (a2) (which can be part of the carrier) for binding structure (a1), and component (b1) comprises a binding structure (b1) for binding structure (a1), active substance (a1), carrier (a2) or binding structure (a2), a coating substance which can contain the binding structure (b1), an enzymatically cleavable linking member and an anionic side group.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 47/26 (2006.01); A61K 47/30 (2006.01); A61K 47/42 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); C12N 15/88 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 35/00 (2017.12); C12N 15/88 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); A61K 2121/00 (2013.01)
Citation (search report)
See references of WO 0138552A2
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
DE 19956029 A1 20010523; AU 1520201 A 20010604; CA 2391922 A1 20010531; EP 1235922 A2 20020904; JP 2003514895 A 20030422; MX PA02004532 A 20020902; WO 0138552 A2 20010531; WO 0138552 A3 20020328
DOCDB simple family (application)
DE 19956029 A 19991122; AU 1520201 A 20001109; CA 2391922 A 20001109; EP 0011055 W 20001109; EP 00977515 A 20001109; JP 2001539894 A 20001109; MX PA02004532 A 20001109