Global Patent Index - EP 1235923 A1

EP 1235923 A1 2002-09-04 - BIOCATALYTIC EPOXIDATION OF VINYLAROMATIC COMPOUNDS

Title (en)

BIOCATALYTIC EPOXIDATION OF VINYLAROMATIC COMPOUNDS

Title (de)

BIOKATALYTISCHE EPOXIDIERUNG VON VINYLAROMATISCHEN VERBINDUNGEN

Title (fr)

EPOXYDATION BIOCATALYTIQUE DE COMPOSES VINYLAROMATIQUES

Publication

EP 1235923 A1 (EN)

Application

EP 00981282 A

Priority

  • EP 00981282 A
  • EP 0011545 W
  • EP 99203857 A

Abstract (en)

[origin: WO0136654A1] Methods for preparation of biocatalysts and processes for application of these biocatalysts for the preparation of selected optically active epoxides with high enantiomeric purity. The methods are based on the stereoselective insertion of an oxygen atom derived from molecular oxygen catalyzed by a microbial monooxygenase enzyme like styrene monooxygenase into vinylaromatic compounds like indene or styrene derivatives as an epoxide function. In particular, these methods are useful for the preparation of (1S, 2R) indene oxide. The enzyme preparations can be used in isolated, purified form or as whole cell preparations in specific recombinant hosts expressing the respective genes of microbial monooxygenases like styrene monooxygenase. Methods for preparing isolated enzymes and recombinant hosts as well as application methods for these systems in organic synthesis are described. Biocatalytic reactions are performed in aqueous medium or in multiphase media possibly containing one or more of the following: a solid phase, an aqueous phase, an organic phase, or a gaseous phase.

IPC 1-7 (main, further and additional classification)

C12P 17/02

IPC 8 full level (invention and additional information)

C12N 9/02 (2006.01); C12P 17/02 (2006.01)

CPC (invention and additional information)

C12N 9/0071 (2013.01); C12P 17/02 (2013.01)

Citation (search report)

See references of WO 0136654A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0136654 A1 20010525; AU 1858501 A 20010530; EP 1106699 A1 20010613; EP 1235923 A1 20020904; JP 2003514536 A 20030422

INPADOC legal status


2006-09-06 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20060314

2002-09-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020524

2002-09-04 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-04 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI