EP 1237844 A1 20020911 - PROCESS FOR THE PREPARATION OF SECONDARY AND TERTIARY AMINES
Title (en)
PROCESS FOR THE PREPARATION OF SECONDARY AND TERTIARY AMINES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON SEKUNDÄREN UND TERTIÄREN AMINEN
Title (fr)
PROCEDE DE PREPARATION D'AMINES SECONDAIRES
Publication
Application
Priority
- US 0026581 W 20000927
- US 17052199 P 19991214
Abstract (en)
[origin: CA2394519A1] N,N-disubstituted amines in which the amino nitrogen atom is bound to the carbon of an aromatic ring disubstituted in the positions ortho to the carbo n atom, are prepared by allowing a primary amine and a compound in which an ortho, ortho-disubstituted aromatic compound carrying a nucleofuge substituent, to react in a basic environment in the presence of a catalytic palladium(0) complex and a ligand, the ratio of palladium complex to ligand being greater than at least 1:1. A typical embodiment involves the reaction of 2-methyl-6-ethylphenyl-trifluoromethylsulfonate and (S)-1-methoxy-2- aminopropane in the presence of bis(dibenzylideneacetone)palladium, tri-tert .- butylphosphine, and sodium tert.-butoxide to yield (S)-N-(1-methoxyprop-2-yl )- 2-methyl-6-ethylphenylamine.
IPC 1-7
IPC 8 full level
C07C 209/00 (2006.01)
IPC 8 main group level
C07C (2006.01)
Citation (search report)
See references of WO 0144162A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
BR 0016348 A 20021217; CA 2394519 A1 20010621; EP 1237844 A1 20020911; FI 20020955 A 20020521
DOCDB simple family (application)
BR 0016348 A 20000927; CA 2394519 A 20000927; EP 00966976 A 20000927; FI 20020955 A 20020521