Global Patent Index - EP 1237844 A1

EP 1237844 A1 2002-09-11 - PROCESS FOR THE PREPARATION OF SECONDARY AND TERTIARY AMINES

Title (en)

PROCESS FOR THE PREPARATION OF SECONDARY AND TERTIARY AMINES

Title (de)

VERFAHREN ZUR HERSTELLUNG VON SEKUNDÄREN UND TERTIÄREN AMINEN

Title (fr)

PROCEDE DE PREPARATION D'AMINES SECONDAIRES

Publication

EP 1237844 A1 (EN)

Application

EP 00966976 A

Priority

  • US 0026581 W
  • US 17052199 P

Abstract (en)

[origin: CA2394519A1] N,N-disubstituted amines in which the amino nitrogen atom is bound to the carbon of an aromatic ring disubstituted in the positions ortho to the carbo n atom, are prepared by allowing a primary amine and a compound in which an ortho, ortho-disubstituted aromatic compound carrying a nucleofuge substituent, to react in a basic environment in the presence of a catalytic palladium(0) complex and a ligand, the ratio of palladium complex to ligand being greater than at least 1:1. A typical embodiment involves the reaction of 2-methyl-6-ethylphenyl-trifluoromethylsulfonate and (S)-1-methoxy-2- aminopropane in the presence of bis(dibenzylideneacetone)palladium, tri-tert .- butylphosphine, and sodium tert.-butoxide to yield (S)-N-(1-methoxyprop-2-yl )- 2-methyl-6-ethylphenylamine.

IPC 1-7 (main, further and additional classification)

C07C 209/00

IPC 8 full level (invention and additional information)

C07C 209/00 (2006.01)

IPC 8 main group level (invention and additional information)

C07C (2006.01)

Citation (search report)

See references of WO 0144162A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

Designated extension state (EPC)

AL LT LV MK RO SI

EPO simple patent family

BR 0016348 A 20021217; CA 2394519 A1 20010621; EP 1237844 A1 20020911; FI 20020955 A 20020521

INPADOC legal status


2007-08-08 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: LIN, SUE, L.

2007-08-08 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: ZHOU, WEIXIA, M.

2007-08-08 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: MATCHAM, GEORGE, W.

2004-03-24 [18W] APPLICATION WITHDRAWN

- Effective date: 20040130

2002-11-06 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: LIN, SUE, L.

2002-11-06 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: ZHOU, WEIXIA, M.

2002-11-06 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: MATCHAM, GEORGE, W.

2002-09-11 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020530

2002-09-11 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2002-09-11 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL PAYMENT 20020530;LT PAYMENT 20020530;LV PAYMENT 20020530;MK PAYMENT 20020530;RO PAYMENT 20020530;SI PAYMENT 20020530