Global Patent Index - EP 1237848 A1

EP 1237848 A1 2002-09-11 - PROCESS FOR THE PREPARATION OF 3-AMINO-3-CYCLOPROPYLPROPANOATE ESTERS

Title (en)

PROCESS FOR THE PREPARATION OF 3-AMINO-3-CYCLOPROPYLPROPANOATE ESTERS

Title (de)

VERFAHREN ZUR HERSTELLUNG VON 3-AMINO-3-CYCLOPROPYLPROPIONSÄUREESTERN

Title (fr)

PROCEDE DE PREPARATION D'ESTERS DE 3-AMINO-3-CYCLOPROPYLPROPANOATE

Publication

EP 1237848 A1 (EN)

Application

EP 00984283 A

Priority

  • US 0033732 W
  • US 46518799 A

Abstract (en)

[origin: WO0144169A1] Disclosed is a process for preparing 3-amino-3-cyclopropylpropanoate esters, i.e., beta -cyclopropylalanine esters ( beta -CPA esters) including racemic and substantially enantiomerically-pure <i>R</i> or (<i>S</i>)- beta -CPA esters. The process comprises reacting cyclopropanecarboxaldehyde (CPCA) with a phosphonate reagent to obtain an alpha , beta -unsaturated ester which is reacted with an enantiomerically-enriched lithium amide to produce an arylalkyl-amino ester compound; and then removing the arylalkyl residue from the amino group by hydrogenolysis to give the beta -CPA ester.

IPC 1-7 (main, further and additional classification)

C07C 229/34; C07C 67/343; C07C 227/06

IPC 8 full level (invention and additional information)

C07C 227/06 (2006.01); C07C 229/34 (2006.01); C07C 229/28 (2006.01)

CPC (invention and additional information)

C07C 227/06 (2013.01); C07C 229/34 (2013.01); C07C 2601/02 (2017.05)

Combination set (CPC)

C07C 227/06 + C07C 229/28

Citation (search report)

See references of WO 0144169A1

Designated contracting state (EPC)

CH DE FR GB LI

EPO simple patent family

WO 0144169 A1 20010621; EP 1237848 A1 20020911

INPADOC legal status


2005-06-15 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20041127

2004-05-19 [RBV] DESIGNATED CONTRACTING STATES (CORRECTION)

- Designated State(s): CH DE FR GB LI

2004-01-14 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031128

2002-09-11 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020529

2002-09-11 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR