EP 1237848 A1 20020911 - PROCESS FOR THE PREPARATION OF 3-AMINO-3-CYCLOPROPYLPROPANOATE ESTERS
Title (en)
PROCESS FOR THE PREPARATION OF 3-AMINO-3-CYCLOPROPYLPROPANOATE ESTERS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON 3-AMINO-3-CYCLOPROPYLPROPIONSÄUREESTERN
Title (fr)
PROCEDE DE PREPARATION D'ESTERS DE 3-AMINO-3-CYCLOPROPYLPROPANOATE
Publication
Application
Priority
- US 0033732 W 20001213
- US 46518799 A 19991215
Abstract (en)
[origin: WO0144169A1] Disclosed is a process for preparing 3-amino-3-cyclopropylpropanoate esters, i.e., beta -cyclopropylalanine esters ( beta -CPA esters) including racemic and substantially enantiomerically-pure <i>R</i> or (<i>S</i>)- beta -CPA esters. The process comprises reacting cyclopropanecarboxaldehyde (CPCA) with a phosphonate reagent to obtain an alpha , beta -unsaturated ester which is reacted with an enantiomerically-enriched lithium amide to produce an arylalkyl-amino ester compound; and then removing the arylalkyl residue from the amino group by hydrogenolysis to give the beta -CPA ester.
IPC 1-7
IPC 8 full level
C07C 227/06 (2006.01); C07C 229/34 (2006.01); C07C 229/28 (2006.01)
CPC (source: EP)
C07C 227/06 (2013.01); C07C 229/34 (2013.01); C07C 2601/02 (2017.04)
Citation (search report)
See references of WO 0144169A1
Designated contracting state (EPC)
CH DE FR GB LI
DOCDB simple family (publication)
DOCDB simple family (application)
US 0033732 W 20001213; EP 00984283 A 20001213