EP 1237849 A1 20020911 - ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE

Title (en)

ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE

Title (de)

AKTIVATOREN DER LÖSLICHEN GUANYLATCYCLASE

Title (fr)

ACTIVATEURS DE LA GUANYLATE CYCLASE SOLUBLE

Publication

EP 1237849 A1 20020911 (EN)

Application

EP 00973061 A 20001106

Priority

GB 0004249 W 20001106
GB 9926286 A 19991105
US 20138200 P 20000502

Abstract (en)

[origin: WO0132604A1] Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the activation of soluble guanylate cyclase, wherein: R1 and R2 are the same or different and each represent a C1-C6 alkyl group, or R1 and R2 together form a C3-C6 alkylene group; Z is a C1-C4 alkylene group; P is a direct bond or a moiety -X-, -Y-, -W-, -XY-, -YW- or -XYW-, wherein; W is -O-, -S-, or -NR3, wherein R3 is hydrogen or C1-C6 alkyl; Y is a moiety -U-V- wherein V is a direct bond or a C1-C6 alkylene group and U is -CS-, -CO-, -S(O)2- or -C(=NR)- wherein R is hydrogen, hydroxy or C1-C6 alkyl; X is -O- or -NR6- wherein R6 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl or heteroaryl; and R4 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, a group -R-A wherein R is -(C1-C6 alkyl)-, -(C2-C6 alkenyl)- or -(C2-C6 alkynyl)- and A is aryl, heteroaryl, carbocyclyl or heterocyclyl, or R4 is a group -COR", -CO2R", -S(O)2R" or -CONR'R" wherein R' is hydrogen, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl and R" is aryl, heteroaryl, carbocyclyl or heterocyclyl.

IPC 1-7

C07C 235/84; C07C 235/50; C07C 235/60; C07D 213/82; C07C 233/78; C07C 235/82; C07D 307/68; C07C 275/36; C07C 275/38; C07C 275/24; A61K 31/165; A61K 31/455; A61K 31/34; A61K 31/17

IPC 8 full level

C07D 237/32 (2006.01); A61K 31/16 (2006.01); A61K 31/166 (2006.01); A61K 31/17 (2006.01); A61K 31/18 (2006.01); A61K 31/27 (2006.01); A61K 31/341 (2006.01); A61K 31/352 (2006.01); A61K 31/381 (2006.01); A61K 31/402 (2006.01); A61K 31/404 (2006.01); A61K 31/415 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/433 (2006.01); A61K 31/4365 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/455 (2006.01); A61K 31/465 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61K 31/497 (2006.01); A61K 31/502 (2006.01); A61K 31/505 (2006.01); A61K 31/517 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 15/06 (2006.01); A61P 15/10 (2006.01); A61P 27/02 (2006.01); A61P 27/06 (2006.01); A61P 43/00 (2006.01); C07C 233/08 (2006.01); C07C 233/36 (2006.01); C07C 233/37 (2006.01); C07C 233/40 (2006.01); C07C 233/62 (2006.01); C07C 233/78 (2006.01); C07C 235/34 (2006.01); C07C 235/50 (2006.01); C07C 235/60 (2006.01); C07C 235/78 (2006.01); C07C 235/82 (2006.01); C07C 235/84 (2006.01); C07C 237/40 (2006.01); C07C 275/16 (2006.01); C07C 275/22 (2006.01); C07C 275/24 (2006.01); C07C 275/26 (2006.01); C07C 275/30 (2006.01); C07C 275/36 (2006.01); C07C 275/38 (2006.01); C07C 275/42 (2006.01); C07C 311/13 (2006.01); C07C 311/21 (2006.01); C07C 311/46 (2006.01); C07C 317/36 (2006.01); C07C 323/62 (2006.01); C07C 323/67 (2006.01); C07D 207/16 (2006.01); C07D 207/34 (2006.01); C07D 209/18 (2006.01); C07D 209/22 (2006.01); C07D 209/42 (2006.01); C07D 213/643 (2006.01); C07D 213/80 (2006.01); C07D 213/82 (2006.01); C07D 215/42 (2006.01); C07D 215/52 (2006.01); C07D 231/14 (2006.01); C07D 231/16 (2006.01); C07D 231/40 (2006.01); C07D 237/30 (2006.01); C07D 239/32 (2006.01); C07D 239/38 (2006.01); C07D 239/95 (2006.01); C07D 241/24 (2006.01); C07D 277/20 (2006.01); C07D 277/28 (2006.01); C07D 277/30 (2006.01); C07D 277/56 (2006.01); C07D 295/13 (2006.01); C07D 307/68 (2006.01); C07D 311/24 (2006.01); C07D 333/36 (2006.01); C07D 333/38 (2006.01); C07D 333/40 (2006.01); C07D 333/56 (2006.01); C07D 333/70 (2006.01); C07D 401/12 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 495/04 (2006.01); C07D 213/64 (2006.01)

CPC (source: EP)

A61P 7/02 (2017.12); A61P 9/00 (2017.12); A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 15/06 (2017.12); A61P 15/10 (2017.12); A61P 27/02 (2017.12); A61P 27/06 (2017.12); A61P 43/00 (2017.12); C07C 233/36 (2013.01); C07C 233/37 (2013.01); C07C 233/40 (2013.01); C07C 233/62 (2013.01); C07C 233/78 (2013.01); C07C 235/34 (2013.01); C07C 235/50 (2013.01); C07C 235/60 (2013.01); C07C 235/78 (2013.01); C07C 235/82 (2013.01); C07C 235/84 (2013.01); C07C 237/40 (2013.01); C07C 275/16 (2013.01); C07C 275/24 (2013.01); C07C 275/26 (2013.01); C07C 275/30 (2013.01); C07C 275/36 (2013.01); C07C 275/38 (2013.01); C07C 275/42 (2013.01); C07C 323/62 (2013.01); C07C 323/67 (2013.01); C07D 207/16 (2013.01); C07D 207/34 (2013.01); C07D 209/18 (2013.01); C07D 209/22 (2013.01); C07D 209/42 (2013.01); C07D 213/643 (2013.01); C07D 213/82 (2013.01); C07D 215/42 (2013.01); C07D 215/52 (2013.01); C07D 231/14 (2013.01); C07D 231/16 (2013.01); C07D 231/40 (2013.01); C07D 237/30 (2013.01); C07D 239/38 (2013.01); C07D 239/95 (2013.01); C07D 241/24 (2013.01); C07D 277/28 (2013.01); C07D 277/30 (2013.01); C07D 277/56 (2013.01); C07D 295/13 (2013.01); C07D 307/68 (2013.01); C07D 311/24 (2013.01); C07D 333/36 (2013.01); C07D 333/38 (2013.01); C07D 333/56 (2013.01); C07D 401/12 (2013.01); C07D 405/04 (2013.01); C07D 409/04 (2013.01); C07D 417/04 (2013.01); C07D 471/04 (2013.01); C07D 495/04 (2013.01); C07C 2601/08 (2017.04); C07C 2601/14 (2017.04); C07C 2601/16 (2017.04); C07C 2602/08 (2017.04); C07C 2603/50 (2017.04)

Citation (search report)

See references of WO 0132604A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0132604 A1 20010510; AU 1161601 A 20010514; CA 2389773 A1 20010510; EP 1237849 A1 20020911; JP 2003513064 A 20030408

DOCDB simple family (application)

GB 0004249 W 20001106; AU 1161601 A 20001106; CA 2389773 A 20001106; EP 00973061 A 20001106; JP 2001534758 A 20001106