EP 1238069 A2 20020911 - ANTISENSE OLIGONUCLEOTIDES FOR METABOTROPIC GLUTAMATE RECEPTOR TYPE 1 (MGLUR1)
Title (en)
ANTISENSE OLIGONUCLEOTIDES FOR METABOTROPIC GLUTAMATE RECEPTOR TYPE 1 (MGLUR1)
Title (de)
ANTISENSE OLIGONUCLEOTIDEN FÜR MGLUR1
Title (fr)
OLIGONUCLEOTIDES DE RECEPTEUR TYPE 1 DE GLUTAMATE METABOTROPIQUE (MGLUR1)
Publication
Application
Priority
- CA 0000824 W 20000717
- US 14400499 P 19990715
Abstract (en)
[origin: WO0105963A2] The present invention relates to antisense oligonucleotides for metabotropic glutamate receptor type 1 (mGluR1). There is provided oligonucleotides that hybridize to a mRNA encoding mGluR1 or a splice variant thereof. There is also provided a method for treating a patient having a disorder related to an elevated glutamate level, such as chronic pain, or to enhance an opioid effect or to reduce opioid dependence and/or tolerance, which comprises the administration of such an oligonucleotide. Specific pain treatment is thereby obtained.
IPC 1-7
IPC 8 full level
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
C12N 15/1138 (2013.01); A61K 38/00 (2013.01); C12N 2310/312 (2013.01); C12N 2310/3125 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3511 (2013.01)
Citation (search report)
See references of WO 0105963A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0105963 A2 20010125; WO 0105963 A3 20011108; AU 5959900 A 20010205; CA 2377937 A1 20010125; EP 1238069 A2 20020911
DOCDB simple family (application)
CA 0000824 W 20000717; AU 5959900 A 20000717; CA 2377937 A 20000717; EP 00945507 A 20000717