Global Patent Index - EP 1238080 A2

EP 1238080 A2 2002-09-11 - BCL-G POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE

Title (en)

BCL-G POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE

Title (de)

BCL-G POLYPEPTIDE, KODIERENDE NUKLEINE SÄUREN UND VERFAHREN ZUR ANWENDUNGEN

Title (fr)

POLYPEPTIDES BCL-G, ACIDES NUCLEIQUE DE CODAGE ET LEURS PROCEDES D'UTILISATION

Publication

EP 1238080 A2 (EN)

Application

EP 00989249 A

Priority

  • US 0033793 W
  • US 46164199 A

Abstract (en)

[origin: WO0144282A2] The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a BcL-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A01K 67/027; A61K 38/17; A61K 48/00; C07K 14/47; C07K 16/18; C12N 15/11; C12N 15/62; C12Q 1/68; G01N 33/53; G01N 33/68

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); A61K 31/7088 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/06 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01); G01N 33/574 (2006.01)

CPC (invention and additional information)

C07K 14/4747 (2013.01); C12Q 1/6886 (2013.01); A01K 2217/05 (2013.01); A61K 38/00 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/136 (2013.01)

Citation (search report)

See references of WO 0144282A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0144282 A2 20010621; WO 0144282 A3 20020221; AU 2578401 A 20010625; CA 2390662 A1 20010621; EP 1238080 A2 20020911; JP 2003516744 A 20030520

INPADOC legal status


2005-08-03 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20041231

2004-03-17 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040128

2002-09-11 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020628

2002-09-11 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-11 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI