Global Patent Index - EP 1238109 A2

EP 1238109 A2 2002-09-11 - METHODS AND KITS FOR DISCOVERY OF RNA-BINDING ANTIMICROBIALS

Title (en)

METHODS AND KITS FOR DISCOVERY OF RNA-BINDING ANTIMICROBIALS

Title (de)

METHODEN UND TESTSÄTZE ZUR ENTDECKUNG VON RNA-BINDENDEN ANTIMIKROBIELLEN SUBSTANZEN

Title (fr)

PROCEDES ET KITS PERMETTANT DE DECOUVRIR DES ANTIMICROBIENS SE LIANT A L'ARN

Publication

EP 1238109 A2 (EN)

Application

EP 00985595 A

Priority

  • GB 0004844 W
  • GB 9929810 A
  • US 46535599 A

Abstract (en)

[origin: WO0144505A2] The invention provides a method for determining whether a test compound binds to a target RNA, the method comprising the steps of: a) contacting the test compound with a pair of indicator molecules comprising an antimicrobial labelled with a donor group or an acceptor group and the target RNA labelled with a complementary acceptor or donor group, the pair being capable of binding to each other in an orientation that permits the donor group to come into sufficient proximity to the acceptor group to permit fluorescent resonance energy transfer and/or quenching to take place; and b) measuring the fluorescence of the target RNA and/or the antimicrobial in the presence of the test compound and comparing this value to the fluorescence of a standard.

IPC 1-7 (main, further and additional classification)

C12Q 1/68

IPC 8 full level (invention and additional information)

C07H 21/02 (2006.01); C07K 7/08 (2006.01); C07K 7/64 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12Q 1/6818 (2013.01); C12Q 1/689 (2013.01)

Combination set (CPC)

C12Q 1/6818 + C12Q 2545/114 + C12Q 2522/101

Citation (search report)

See references of WO 0144505A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0144505 A2 20010621; WO 0144505 A3 20011220; AU 2200401 A 20010625; EP 1238109 A2 20020911; GB 0030862 D0 20010131; GB 2359357 A8 20020304; GB 2359357 A 20010822

INPADOC legal status


2005-06-29 [18W] APPLICATION WITHDRAWN

- Effective date: 20050415

2004-01-02 [RAP1] TRANSFER OF RIGHTS OF AN APPLICATION

- Owner name: VERNALIS (CAMBRIDGE) LIMITED

2003-09-03 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030716

2002-09-11 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020619

2002-09-11 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-11 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI