EP 1238285 A1 20020911 - STEROID COMPOUNDS FOR STEROID RECEPTOR BINDING ASSAYS
Title (en)
STEROID COMPOUNDS FOR STEROID RECEPTOR BINDING ASSAYS
Title (de)
STEROIDVERBINDUNGEN ZUR STEROIDREZEPTOREN-BINDUNGSASSAYS
Title (fr)
COMPOSES STEROIDIQUES DESTINES A DES DOSAGES PAR LIAISON DE RECEPTEUR DE STEROIDES
Publication
Application
Priority
- EP 00989893 A 20001124
- EP 0011803 W 20001124
- EP 99204036 A 19991130
Abstract (en)
[origin: WO0140805A1] The invention provides a compound having binding affinity for a receptor and comprising a steroid skeleton in its molecular structure, which compound is according to formula (1) wherein: Bu is a sterically bulky structure or Bu is a molecular moiety having high affinity for a sterically bulky molecular structure; A is -NH-, -O-, -C(O)- or -S-; Y is a branched or unbranched, saturated or unsaturated chain of 2 to 18 atoms of carbon, which chain is optionally interrupted by replacements of carbon atoms by oxygen, nitrogen or sulfur atoms and is optionally substituted with keto, hydroxyl, sulfhydryl or halogen groups; X is a carbon atom or an arylene group linked to the steroid skeleton with a carbon or an oxygen atom; Ste is a group with a steroidal skeleton, having binding affinity for a steroid receptor; and dotted lines represent optional double or triple bonds. The invention also provides for a method for determination of binding between a compound having a molecular group L in its molecular structure and a compound having a molecular group R in its molecular structure, in which method L is the group Ste as defined above and R is a steroid receptor.
IPC 1-7
IPC 8 full level
C07J 31/00 (2006.01); C07J 41/00 (2006.01); C07J 43/00 (2006.01); G01N 33/533 (2006.01); G01N 33/74 (2006.01)
CPC (source: EP)
C07J 31/006 (2013.01); C07J 41/0083 (2013.01); C07J 43/003 (2013.01); G01N 33/533 (2013.01); G01N 33/743 (2013.01); G01N 2333/723 (2013.01)
Citation (search report)
See references of WO 0140805A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
DOCDB simple family (application)
EP 0011803 W 20001124; EP 00989893 A 20001124