Global Patent Index - EP 1238285 A1

EP 1238285 A1 2002-09-11 - STEROID COMPOUNDS FOR STEROID RECEPTOR BINDING ASSAYS

Title (en)

STEROID COMPOUNDS FOR STEROID RECEPTOR BINDING ASSAYS

Title (de)

STEROIDVERBINDUNGEN ZUR STEROIDREZEPTOREN-BINDUNGSASSAYS

Title (fr)

COMPOSES STEROIDIQUES DESTINES A DES DOSAGES PAR LIAISON DE RECEPTEUR DE STEROIDES

Publication

EP 1238285 A1 (EN)

Application

EP 00989893 A

Priority

  • EP 00989893 A
  • EP 0011803 W
  • EP 99204036 A

Abstract (en)

[origin: WO0140805A1] The invention provides a compound having binding affinity for a receptor and comprising a steroid skeleton in its molecular structure, which compound is according to formula (1) wherein: Bu is a sterically bulky structure or Bu is a molecular moiety having high affinity for a sterically bulky molecular structure; A is -NH-, -O-, -C(O)- or -S-; Y is a branched or unbranched, saturated or unsaturated chain of 2 to 18 atoms of carbon, which chain is optionally interrupted by replacements of carbon atoms by oxygen, nitrogen or sulfur atoms and is optionally substituted with keto, hydroxyl, sulfhydryl or halogen groups; X is a carbon atom or an arylene group linked to the steroid skeleton with a carbon or an oxygen atom; Ste is a group with a steroidal skeleton, having binding affinity for a steroid receptor; and dotted lines represent optional double or triple bonds. The invention also provides for a method for determination of binding between a compound having a molecular group L in its molecular structure and a compound having a molecular group R in its molecular structure, in which method L is the group Ste as defined above and R is a steroid receptor.

IPC 1-7 (main, further and additional classification)

G01N 33/74; C07J 31/00; C07J 41/00; C07J 43/00; G01N 33/533

IPC 8 full level (invention and additional information)

C07J 31/00 (2006.01); C07J 41/00 (2006.01); C07J 43/00 (2006.01); G01N 33/533 (2006.01); G01N 33/74 (2006.01)

CPC (invention and additional information)

G01N 33/533 (2013.01); C07J 31/006 (2013.01); C07J 41/0083 (2013.01); C07J 43/003 (2013.01); G01N 33/743 (2013.01); G01N 2333/723 (2013.01)

Citation (search report)

See references of WO 0140805A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0140805 A1 20010607; EP 1238285 A1 20020911

INPADOC legal status


2004-12-08 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20040531

2002-09-11 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020701

2002-09-11 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR