Global Patent Index - EP 1239864 A1

EP 1239864 A1 2002-09-18 - TREATMENT OF HEART RHYTHM DISTURBANCES WITH N6 -SUBSTITUTED-5'-(N-SUBSTITUTED) CARBOXAMIDOADENOSINES

Title (en)

TREATMENT OF HEART RHYTHM DISTURBANCES WITH N6 -SUBSTITUTED-5'-(N-SUBSTITUTED) CARBOXAMIDOADENOSINES

Title (de)

BEHANDLUNG VON HERZRHYTHMUSSTÖRUNGEN MITTELS N6-SUBSTITUIERTE-5'-(N-SUBSTITUIERTE) CARBOXAMIDOADENOSINE

Title (fr)

TRAITEMENT DES TROUBLES DU RYTHME CARDIAQUE AU MOYEN DE CARBOXAMIDOADENOSINES N?6 -SUBSTITUTEES-5'-(N-SUBSTITUTEES)

Publication

EP 1239864 A1 (EN)

Application

EP 00978700 A

Priority

  • US 0031417 W
  • US 16701499 P

Abstract (en)

[origin: WO0137845A1] The present invention discloses a method for treating heart rhythm disturbances in a mammal in need thereof by the administration of N<6>-substituted-5'-(N-substituted)carboxamidoadenosines. More particularly, the invention is directed to a method for treatment of heart rhythm disturbances in a mammal that would benefit from the induction of negative dromotropic and/or negative chronotropic actions, comprising the administration to said mammal of an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt or ester thereof; wherein R1 is C3-7 secondary alkyl, or C3-8 cycloalkyl; and R2 is C1-4 alkyl or C3-5 cycloalkyl. The invention is also directed to novel dosage forms comprising said compounds.

IPC 1-7 (main, further and additional classification)

A61K 31/7076; A61P 9/06

IPC 8 full level (invention and additional information)

C07H 19/16 (2006.01); A61K 31/7076 (2006.01); A61P 9/00 (2006.01); A61P 9/06 (2006.01); C07H 19/167 (2006.01)

IPC 8 main group level (invention and additional information)

A61K (2006.01); C07H (2006.01)

CPC (invention and additional information)

A61K 31/7076 (2013.01)

Citation (search report)

See references of WO 0137845A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0137845 A1 20010531; AU 1613201 A 20010604; AU 782715 B2 20050825; CA 2392369 A1 20010531; EP 1239864 A1 20020918; IL 149470 D0 20021110; JP 2003514863 A 20030422; MX PA02005088 A 20040823; MY 135962 A 20080731; NO 20022393 A 20020624; NO 20022393 D0 20020521; NZ 518861 A 20041126; TW I257306 B 20060701

INPADOC legal status


2007-04-11 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20060930

2004-04-21 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040308

2002-09-18 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020624

2002-09-18 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-18 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL PAYMENT 20020624;LT PAYMENT 20020624;LV PAYMENT 20020624;MK PAYMENT 20020624;RO PAYMENT 20020624;SI PAYMENT 20020624