Global Patent Index - EP 1240127 A1

EP 1240127 A1 2002-09-18 - PROCESS FOR THE PRODUCTION OF TRIFLUOROMETHYLACETOPHENONES

Title (en)

PROCESS FOR THE PRODUCTION OF TRIFLUOROMETHYLACETOPHENONES

Title (de)

VERFAHREN ZUR HERSTELLUNG VON TRIFLUORMETHYLACETOPHENONEN

Title (fr)

PRODUCTION DE TRIFLUOROMETHYLACETOPHENONES

Publication

EP 1240127 A1 (EN)

Application

EP 00975941 A

Priority

  • EP 0010596 W
  • GB 9929562 A

Abstract (en)

[origin: WO0144152A1] The invention provides a novel process for the preparation of trifluoromethylacetophenones of general formula (I), wherein the position of the CF3-group on the aromatic ring may be in the 2- or 3-position relative to the acetyl, which process comprises (a) reacting a trifluoromethylbenzoyl halide of general formula (II), wherein the position of the CF3-group on the aromatic ring may be in the 2- or 3-position relative to the acetyl and Hal is a halogen atom selected from the group consisting of fluorine, chlorine, bromine, and iodine, with a cyclic secondary amine of general formula (III), wherein A is C3-C7-alkylene bridge which may be interrupted by a oxygen or sulfur atom in the presence of an aqueous base, used as an acid acceptor, resulting in the formation of a cycloalkyl-trifluoromethylbenzamide of general formula (IV), wherein the position of the CF3-group on the aromatic ring and A are as defined above, and (b) adding a methyl Grignard reagent to said cycloalkyl-trifluoromethylbenzamide followed by acidification with an aqueous acidification reagent to form the trifluoromethylacetophenone of formula (I).

IPC 1-7 (main, further and additional classification)

C07C 45/00; C07C 45/56; C07C 49/80

IPC 8 full level (invention and additional information)

C07C 45/56 (2006.01); C07C 45/00 (2006.01); C07C 45/45 (2006.01); C07C 49/80 (2006.01)

CPC (invention and additional information)

C07C 45/004 (2013.01)

Combination set (CPC)

C07C 45/004 + C07C 49/80

Citation (search report)

See references of WO 0144152A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0144152 A1 20010621; AU 1388901 A 20010625; BR 0016320 A 20020827; CN 1409697 A 20030409; EP 1240127 A1 20020918; GB 9929562 D0 20000209; IL 149713 D0 20021110; JP 2003517029 A 20030520; KR 20020056943 A 20020710; MX PA02005873 A 20030128

INPADOC legal status


2004-06-16 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20031104

2003-08-06 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030623

2002-11-27 [RAP1] TRANSFER OF RIGHTS OF AN APPLICATION

- Owner name: BAYER CROPSCIENCE AG

2002-09-18 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020715

2002-09-18 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2002-09-18 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI