EP 1240127 A1 20020918 - PROCESS FOR THE PRODUCTION OF TRIFLUOROMETHYLACETOPHENONES
Title (en)
PROCESS FOR THE PRODUCTION OF TRIFLUOROMETHYLACETOPHENONES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON TRIFLUORMETHYLACETOPHENONEN
Title (fr)
PRODUCTION DE TRIFLUOROMETHYLACETOPHENONES
Publication
Application
Priority
- EP 0010596 W 20001027
- GB 9929562 A 19991214
Abstract (en)
[origin: WO0144152A1] The invention provides a novel process for the preparation of trifluoromethylacetophenones of general formula (I), wherein the position of the CF3-group on the aromatic ring may be in the 2- or 3-position relative to the acetyl, which process comprises (a) reacting a trifluoromethylbenzoyl halide of general formula (II), wherein the position of the CF3-group on the aromatic ring may be in the 2- or 3-position relative to the acetyl and Hal is a halogen atom selected from the group consisting of fluorine, chlorine, bromine, and iodine, with a cyclic secondary amine of general formula (III), wherein A is C3-C7-alkylene bridge which may be interrupted by a oxygen or sulfur atom in the presence of an aqueous base, used as an acid acceptor, resulting in the formation of a cycloalkyl-trifluoromethylbenzamide of general formula (IV), wherein the position of the CF3-group on the aromatic ring and A are as defined above, and (b) adding a methyl Grignard reagent to said cycloalkyl-trifluoromethylbenzamide followed by acidification with an aqueous acidification reagent to form the trifluoromethylacetophenone of formula (I).
IPC 1-7
IPC 8 full level
C07C 45/00 (2006.01); C07C 45/45 (2006.01); C07C 45/56 (2006.01); C07C 49/80 (2006.01)
CPC (source: EP KR)
C07C 45/004 (2013.01 - EP); C07C 45/61 (2013.01 - KR)
Citation (search report)
See references of WO 0144152A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0144152 A1 20010621; AU 1388901 A 20010625; BR 0016320 A 20020827; CN 1409697 A 20030409; EP 1240127 A1 20020918; GB 9929562 D0 20000209; HK 1052926 A1 20031003; IL 149713 A0 20021110; JP 2003517029 A 20030520; KR 20020056943 A 20020710; MX PA02005873 A 20030128
DOCDB simple family (application)
EP 0010596 W 20001027; AU 1388901 A 20001027; BR 0016320 A 20001027; CN 00816915 A 20001027; EP 00975941 A 20001027; GB 9929562 A 19991214; HK 03105240 A 20030721; IL 14971300 A 20001027; JP 2001545242 A 20001027; KR 20027006569 A 20020523; MX PA02005873 A 20001027