Global Patent Index - EP 1240144 A2

EP 1240144 A2 2002-09-18 - COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION

Title (en)

COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION

Title (de)

VERBINDUNGEN ZUR FÖRDERUNG DER NEURONENDIFFERENZIERUNG

Title (fr)

AGENTS NEUROPROTECTEURS ET METHODES ASSOCIEES

Publication

EP 1240144 A2 (EN)

Application

EP 00976295 A

Priority

  • JP 0008090 W
  • US 45024599 A

Abstract (en)

[origin: WO0140187A2] Neuroprotective agents are disclosed having structure: (I) and stereoisomers and pharmaceutically acceptable salts thereof, wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl or substituted heterocyclealkyl; R2 is -OR2a or -NR2bR2c; R3 is hydrogen, keto, -C(=O)OR3a or -C(=O)NR3bR3c; R4 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, -C(=O)R4a, -C(=O)OR4b, -C(=O)NR4cR4d, -OC(=O)NR4cR4d or -SO2R4c or wherein R3 and R4 taken together form a heterocyclic ring or substituted heterocyclic ring; and R5 is hydrogen, alkyl or substituted alkyl. Such compounds have utility in the treatment of conditions which benefit from administration of neuroprotective agents generally, including treatment of central and peripheral nervous condition as well as promoting nerve cell differentiation. Methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more of the compounds of this invention.

[origin: WO0140187A2] Neuroprotective agents are disclosed having structure (I) wherein R1, R2, R3, R4 and R5 are as defined herein. Such compounds have utility in the treatment of conditions which benefit from administration of neuroprotective agents generally, including treatment of central and peripheral nervous condition as well as for promoting nerve cell differentiation. Methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more of the compounds of this invention.

IPC 1-7 (main, further and additional classification)

C07D 213/55; A61K 31/44; A61P 25/00; C07D 213/56; C07D 417/12

IPC 8 full level (invention and additional information)

C07D 213/55 (2006.01); A61K 31/4406 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/498 (2006.01); A61K 31/5377 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07C 323/59 (2006.01); C07D 213/50 (2006.01); C07D 213/56 (2006.01); C07D 213/81 (2006.01); C07D 239/26 (2006.01); C07D 277/24 (2006.01); C07D 277/64 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 407/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 495/04 (2006.01)

CPC (invention and additional information)

C07D 213/81 (2013.01); C07C 323/59 (2013.01); C07D 213/50 (2013.01); C07D 239/26 (2013.01); C07D 277/24 (2013.01); C07D 277/64 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 495/04 (2013.01)

Citation (search report)

See references of WO 0140187A3

Designated contracting state (EPC)

DE ES FR GB IT

EPO simple patent family

WO 0140187 A2 20010607; WO 0140187 A3 20020711; AR 026609 A1 20030219; AU 1414101 A 20010612; CA 2388239 A1 20010607; EP 1240144 A2 20020918; JP 2003515589 A 20030507

INPADOC legal status


2008-03-26 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20071005

2007-06-27 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20070524

2004-05-12 [RBV] DESIGNATED CONTRACTING STATES (CORRECTION)

- Designated State(s): DE ES FR GB IT

2002-09-18 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020410

2002-09-18 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2002-09-18 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI