EP 1240144 A2 20020918 - COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION
Title (en)
COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION
Title (de)
VERBINDUNGEN ZUR FÖRDERUNG DER NEURONENDIFFERENZIERUNG
Title (fr)
AGENTS NEUROPROTECTEURS ET METHODES ASSOCIEES
Publication
Application
Priority
- JP 0008090 W 20001116
- US 45024599 A 19991129
Abstract (en)
[origin: WO0140187A2] Neuroprotective agents are disclosed having structure (I) wherein R1, R2, R3, R4 and R5 are as defined herein. Such compounds have utility in the treatment of conditions which benefit from administration of neuroprotective agents generally, including treatment of central and peripheral nervous condition as well as for promoting nerve cell differentiation. Methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more of the compounds of this invention.
[origin: WO0140187A2] Neuroprotective agents are disclosed having structure: (I) and stereoisomers and pharmaceutically acceptable salts thereof, wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl or substituted heterocyclealkyl; R2 is -OR2a or -NR2bR2c; R3 is hydrogen, keto, -C(=O)OR3a or -C(=O)NR3bR3c; R4 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, -C(=O)R4a, -C(=O)OR4b, -C(=O)NR4cR4d, -OC(=O)NR4cR4d or -SO2R4c or wherein R3 and R4 taken together form a heterocyclic ring or substituted heterocyclic ring; and R5 is hydrogen, alkyl or substituted alkyl. Such compounds have utility in the treatment of conditions which benefit from administration of neuroprotective agents generally, including treatment of central and peripheral nervous condition as well as promoting nerve cell differentiation. Methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more of the compounds of this invention.
IPC 1-7
C07D 213/55; C07D 213/56; C07D 417/12; A61K 31/44; A61P 25/00
IPC 8 full level
A61K 31/4406 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/498 (2006.01); A61K 31/5377 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07C 323/59 (2006.01); C07D 213/50 (2006.01); C07D 213/55 (2006.01); C07D 213/56 (2006.01); C07D 213/81 (2006.01); C07D 239/26 (2006.01); C07D 277/24 (2006.01); C07D 277/64 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 407/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 495/04 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 21/00 (2017.12); A61P 25/00 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); C07C 323/59 (2013.01); C07D 213/50 (2013.01); C07D 213/81 (2013.01); C07D 239/26 (2013.01); C07D 277/24 (2013.01); C07D 277/64 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 495/04 (2013.01)
Citation (search report)
See references of WO 0140187A2
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 0140187 A2 20010607; WO 0140187 A3 20020711; AR 026609 A1 20030219; AU 1414101 A 20010612; CA 2388239 A1 20010607; EP 1240144 A2 20020918; JP 2003515589 A 20030507
DOCDB simple family (application)
JP 0008090 W 20001116; AR P000106223 A 20001127; AU 1414101 A 20001116; CA 2388239 A 20001116; EP 00976295 A 20001116; JP 2001541872 A 20001116