EP 1240201 A1 20020918 - OXIDIZED APOLIPOPROTEINS AND METHODS OF USE
Title (en)
OXIDIZED APOLIPOPROTEINS AND METHODS OF USE
Title (de)
OXIDIERTE APOLIPOPROTEINE UND VERFAHREN ZU DEREN ANWENDUNG
Title (fr)
APOLIPOPROTEINES OXYDEES ET LEURS PROCEDES D'UTILISATION
Publication
Application
Priority
- AU 0001463 W 20001127
- AU PQ429399 A 19991126
Abstract (en)
[origin: WO0138395A1] The present invention relates to oxidized forms of apolipoproteins and methods of use in diagnosis and treatment of diseases associated with oxidative stress, such as cardiovascular diseases, in particular of atherosclerosis. Specifically, oxidized forms of ApoA-1 and ApoA-II having specific methionine residues oxidized are provided. Methods of use include increasing effux and alpha -TOH, lowering lipid concentrations and preventing or treating lipid-associated conditions are provided. Methods of detecting oxidative stress, genotypes and extent of lipid associated conditions are also provided by utilizing the oxidative apolipoproteins.
IPC 1-7
IPC 8 full level
A61K 38/17 (2006.01); A61P 9/06 (2006.01); A61P 9/10 (2006.01); C07K 14/47 (2006.01); C07K 14/775 (2006.01); C12Q 1/68 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 9/06 (2017.12); A61P 9/10 (2017.12); C07K 14/775 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0138395 A1 20010531; AU PQ429399 A0 19991223; CA 2392355 A1 20010531; EP 1240201 A1 20020918; EP 1240201 A4 20040317; JP 2003514918 A 20030422; NZ 519040 A 20040227
DOCDB simple family (application)
AU 0001463 W 20001127; AU PQ429399 A 19991126; CA 2392355 A 20001127; EP 00979269 A 20001127; JP 2001540158 A 20001127; NZ 51904000 A 20001127