Global Patent Index - EP 1240357 A1

EP 1240357 A1 2002-09-18 - INCREMENTALLY TRUNCATED NUCLEIC ACIDS AND METHODS OF MAKING SAME

Title (en)

INCREMENTALLY TRUNCATED NUCLEIC ACIDS AND METHODS OF MAKING SAME

Title (de)

FORTSCHREITEND VERKÜRZTE NUKLEINSÄUREN UND VERFAHREN ZU DEREN HERSTELLUNG

Title (fr)

ACIDES NUCLEIQUES TRONQUES PROGRESSIVEMENT ET PROCEDES PERMETTANT DE LES PREPARER

Publication

EP 1240357 A1 (EN)

Application

EP 00980690 A

Priority

  • US 0032114 W
  • US 17252599 P
  • US 57534500 A
  • US 71846500 A

Abstract (en)

[origin: WO0175158A1] A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all possible single base-pair deletions of a given nucleic acid sequence is created. A method of making shuffled incremental truncated nucleic acids, which is independent of nucleic acid sequence homology is also described, and shown in figure 1. These methods can be used in protein engineering, protein folding, protein evolution, and the chemical synthesis of novel hybrid proteins and polypeptides.

IPC 1-7 (main, further and additional classification)

C12Q 1/68; C07H 21/02; C07H 21/04; C12N 7/00; C12N 15/00

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C07K 14/00 (2006.01); C12N 15/01 (2006.01); C12N 15/10 (2006.01)

CPC (invention and additional information)

C12N 15/102 (2013.01); C12N 15/1027 (2013.01); C12N 15/1058 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0175158 A1 20011011; AU 1791701 A 20011015; CA 2393117 A1 20011011; EP 1240357 A1 20020918; EP 1240357 A4 20031029; JP 2004528801 A 20040924; US 2008227650 A1 20080918; US 2008227659 A1 20080918; US 7332308 B1 20080219; US 7820413 B2 20101026

INPADOC legal status


2005-12-21 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20050601

2004-07-28 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040615

2003-10-29 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20030912

2002-09-18 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020708

2002-09-18 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-18 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL PAYMENT 20020708;LT PAYMENT 20020708;LV PAYMENT 20020708;MK PAYMENT 20020708;RO PAYMENT 20020708;SI PAYMENT 20020708