Global Patent Index - EP 1240520 A2

EP 1240520 A2 2002-09-18 - KIT AND METHOD TO ASSESS THE MALIGNANCY OF NEOPLASIAS

Title (en)

KIT AND METHOD TO ASSESS THE MALIGNANCY OF NEOPLASIAS

Title (de)

KIT UND VERFAHREN ZUR EINSCHÄTZUNG DER BÖSARTIGKEIT VON NEOPLASIEN

Title (fr)

TROUSSE ET PROCEDE POUR EVALUER LA MALIGNITE DES NEOPLASIES

Publication

EP 1240520 A2 (EN)

Application

EP 00956391 A

Priority

  • DE 19936618 A
  • EP 0007557 W

Abstract (en)

[origin: WO0111361A2] The present invention relates to a diagnostic kit and use thereof for the stratification of patients for a treatment of hormone-dependent benign and malignant neoplasias. The kit contains antibodies that are directed against to a proliferation marker, preferably the Ki-67 protein, MCM, PCNA, Cyclines, phosphorylated histones, etc., and in particular the Ki-67 protein, on the one hand, and antibodies that are directed against a second marker selected form the group of hormone receptors such as the estrogen receptor, apoptotic marker like caspase cleaved cytokeratine 18 as defined by the mAb CD30, and bcl-2; transforming cell markers or tumor cell markers, like Her-2/neu on the other hand. The marker indices (e.g. Ki-67 marker index and hormone receptor status) generated with the aid of the antibodies can be set related to each other and serve for an optimal determination of the form of treatment.

IPC 1-7 (main, further and additional classification)

G01N 33/574

IPC 8 full level (invention and additional information)

G01N 33/53 (2006.01); C12Q 1/02 (2006.01); G01N 33/574 (2006.01)

CPC (invention and additional information)

G01N 33/57484 (2013.01); G01N 2333/723 (2013.01)

Citation (search report)

See references of WO 0111361A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 0111361 A2 20010215; WO 0111361 A3 20011115; AU 6835300 A 20010305; DE 19936618 A1 20010315; EP 1240520 A2 20020918; JP 2003506716 A 20030218

INPADOC legal status


2005-09-28 [18R] REFUSED

- Effective date: 20050425

2004-12-01 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: DAKOCYTOMATION DENMARK A/S

2004-07-14 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040526

2002-09-18 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020131

2002-09-18 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2002-09-18 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL;LT;LV;MK;RO;SI