EP 1240520 A2 20020918 - KIT AND METHOD TO ASSESS THE MALIGNANCY OF NEOPLASIAS
Title (en)
KIT AND METHOD TO ASSESS THE MALIGNANCY OF NEOPLASIAS
Title (de)
KIT UND VERFAHREN ZUR EINSCHÄTZUNG DER BÖSARTIGKEIT VON NEOPLASIEN
Title (fr)
TROUSSE ET PROCEDE POUR EVALUER LA MALIGNITE DES NEOPLASIES
Publication
Application
Priority
- DE 19936618 A 19990804
- EP 0007557 W 20000803
Abstract (en)
[origin: WO0111361A2] The present invention relates to a diagnostic kit and use thereof for the stratification of patients for a treatment of hormone-dependent benign and malignant neoplasias. The kit contains antibodies that are directed against to a proliferation marker, preferably the Ki-67 protein, MCM, PCNA, Cyclines, phosphorylated histones, etc., and in particular the Ki-67 protein, on the one hand, and antibodies that are directed against a second marker selected form the group of hormone receptors such as the estrogen receptor, apoptotic marker like caspase cleaved cytokeratine 18 as defined by the mAb CD30, and bcl-2; transforming cell markers or tumor cell markers, like Her-2/neu on the other hand. The marker indices (e.g. Ki-67 marker index and hormone receptor status) generated with the aid of the antibodies can be set related to each other and serve for an optimal determination of the form of treatment.
IPC 1-7
IPC 8 full level
C12Q 1/02 (2006.01); G01N 33/53 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP)
G01N 33/57484 (2013.01); G01N 2333/723 (2013.01)
Citation (search report)
See references of WO 0111361A2
Citation (examination)
- BREAST CANCER RESEARCH AND TREATMENT, vol. 29, 1994, pages 117 - 125
- CANCER RESEARCH, vol. 54, 1 April 1994 (1994-04-01), pages 1684 - 1689
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0111361 A2 20010215; WO 0111361 A3 20011115; AU 6835300 A 20010305; DE 19936618 A1 20010315; EP 1240520 A2 20020918; JP 2003506716 A 20030218
DOCDB simple family (application)
EP 0007557 W 20000803; AU 6835300 A 20000803; DE 19936618 A 19990804; EP 00956391 A 20000803; JP 2001515966 A 20000803