EP 1241934 A1 20020925 - MELANOCORTIN-4 RECEPTOR DEFICIENT CELLS, NON-HUMAN TRANSGENIC ANIMALS AND METHODS OF SELECTING COMPOUNDS WHICH REGULATE BODY WEIGHT
Title (en)
MELANOCORTIN-4 RECEPTOR DEFICIENT CELLS, NON-HUMAN TRANSGENIC ANIMALS AND METHODS OF SELECTING COMPOUNDS WHICH REGULATE BODY WEIGHT
Title (de)
ZELLEN MIT DEFIZIENTEM MELANOCORTIN-4-REZEPTOR, NICHT-MENSCHLICHE TRANSGENE TIERE UND VERFAHREN ZUR AUSWAHL VON SUBSTANZEN, DIE DAS KÖRPERGEWICHT REGULIEREN KÖNNEN
Title (fr)
CELLULES DEFICIENTES EN RECEPTEURS 4 DE MELANOCORTINE, ANIMAUX TRANSGENIQUES NON HUMAINS ET PROCEDES DE SELECTION DE COMPOSES QUI REGULENT LE POIDS CORPOREL
Publication
Application
Priority
- US 0031061 W 20001113
- US 16507499 P 19991112
Abstract (en)
[origin: WO0133956A1] Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding the melcanocortin-4 receptor protein (MC-4R). These MC-4R deficient transgenic animals can be used to select for and test potential modulators of MC-4R. This data allows for methods of screening for preferential MC-4R modulators which effect body weight through modulation of both metabolic rate and food intake, as well as associated methods of treating various disorders associated with inappropriate regulation of body weight.
IPC 1-7
A01K 67/00; C12N 5/06; C12N 5/10; C12N 15/00; C12N 15/85; C12N 15/86; C12Q 1/00
IPC 8 full level
A01K 67/027 (2006.01); C07K 14/72 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12Q 1/02 (2006.01)
CPC (source: EP)
A01K 67/0276 (2013.01); C07K 14/723 (2013.01); C12N 15/8509 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A01K 2217/20 (2013.01); A01K 2227/105 (2013.01); A01K 2227/50 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0362 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0133956 A1 20010517; CA 2390740 A1 20010517; EP 1241934 A1 20020925; EP 1241934 A4 20050427; JP 2003525596 A 20030902
DOCDB simple family (application)
US 0031061 W 20001113; CA 2390740 A 20001113; EP 00980352 A 20001113; JP 2001535977 A 20001113