EP 1242080 A1 20020925 - DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE
Title (en)
DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE
Title (de)
INHIBITOREN VON DOPAMINETRANSPORT UND DEREN VERWENDUNG
Title (fr)
INHIBITEURS DU TRANSPORTEUR DE DOPAMINE ET LEUR UTILISATION
Publication
Application
Priority
- US 0026447 W 20000927
- US 15579799 P 19990927
- US 22658100 P 20000821
Abstract (en)
[origin: WO0122964A1] The present invention provides a novel class of compounds. The compounds are inhibitors of dopamine transporter and therefore are useful in the treatment of disorders related to dopamine transporter activity. One aspect of the present invention provides a class of compounds of formula (I): wherein R1 is an alkyl, aryl, alkyl-aryl, aromatic ring containing one or more hetero atoms; R2 is an alkyl, aryl, aromatic ring containing one or more hetero atoms, ketone, hydroxyl, alcohol, aldehyde, ester, acid, amide group, or (1) or (2), wherein R' is a phenyl ring optionally substituted with one or more halogens or one or more saturated or unsaturated alkyl (C1-5) group, or aromatic ring with one or more hereto atoms optionally substituted with one or more halogens or one or more saturated or unsaturated alkyl (C1-5) group; R3 is F, C1, Br, I, OH, OR', or OC=OR', wherein R' is an alkyl, aryl, aromatic ring containing one or more hetero atoms, or a -O- bond with R2 when R2 is hydroxyl or alcohol; R4 is an alkyl, aryl, alkyl-aryl; aromatic ring containing one or more hetero atoms, hydroxyl, alcohol, aldehyde, ester, acid, amide group.
IPC 1-7
A61K 31/44; A61K 31/445; C07D 211/40; C07D 211/52; C07D 471/02
IPC 8 full level
C07D 211/52 (2006.01); C07D 491/04 (2006.01)
CPC (source: EP)
A61P 25/16 (2017.12); A61P 25/24 (2017.12); A61P 25/30 (2017.12); C07D 211/52 (2013.01); C07D 491/04 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0122964 A1 20010405; CA 2389049 A1 20010405; EP 1242080 A1 20020925; EP 1242080 A4 20030122
DOCDB simple family (application)
US 0026447 W 20000927; CA 2389049 A 20000927; EP 00968417 A 20000927