Global Patent Index - EP 1242088 A1

EP 1242088 A1 2002-09-25 - ORAL MUCOSAL DOSAGE FORMS OF APOMORPHINE

Title (en)

ORAL MUCOSAL DOSAGE FORMS OF APOMORPHINE

Title (de)

ORALE MUCOSALE DOSIERUNGSFORMEN MIT APOMORPHIN

Title (fr)

FORMES POSOLOGIQUES D'APOMORPHINE ADMINISTREE ORALEMENT PAR VOIE MUQUEUSE

Publication

EP 1242088 A1 (EN)

Application

EP 00988174 A

Priority

  • US 0034548 W
  • US 47584499 A

Abstract (en)

[origin: WO0149292A1] A pharmaceutical formulation for the prolonged-release oral mucosal administration of apomorpine which comprises a therapeutically effective amount of apomorphine or a pharmaceutically acceptable salt or pro-drug thereof in combination with a carrier comprising from about 10 percent by weight to about 95 percent by weight dextran, based upon the total weight of the formulation. In one embodiment of the invention, dextran having a molecular weight in the range between about 5000 Daltons and 100,000 Daltons is the sole component of the formulation for prolonging the release of the active drug component. In an alternative embodiment, a mixture of microcrystalline cellulose and dextran act as the components to prolong the release of apomorphine.

IPC 1-7 (main, further and additional classification)

A61K 31/485; A61K 9/00; A61K 9/20

IPC 8 full level (invention and additional information)

C07D 221/18 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 9/22 (2006.01); A61K 31/473 (2006.01); A61K 47/26 (2006.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 43/00 (2006.01)

CPC (invention and additional information)

A61K 9/205 (2013.01); A61K 9/0056 (2013.01); A61K 9/006 (2013.01)

Citation (search report)

See references of WO 0149292A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0149292 A1 20010712; AU 2440901 A 20010716; BR 0012822 A 20040309; CA 2394297 A1 20010712; CN 1414853 A 20030430; CZ 20022245 A3 20021016; EP 1242088 A1 20020925; HU 0400495 A2 20040628; HU 0400495 A3 20070502; IL 150034 D0 20021201; JP 2004501065 A 20040115; MX PA02006034 A 20040823; NO 20023190 A 20020829; NO 20023190 D0 20020701; PL 366204 A1 20050124

INPADOC legal status


2009-07-31 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1051315

2006-04-12 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20051005

2003-05-07 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030325

2002-09-25 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020610

2002-09-25 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR