EP 1242088 A1 20020925 - ORAL MUCOSAL DOSAGE FORMS OF APOMORPHINE
Title (en)
ORAL MUCOSAL DOSAGE FORMS OF APOMORPHINE
Title (de)
ORALE MUCOSALE DOSIERUNGSFORMEN MIT APOMORPHIN
Title (fr)
FORMES POSOLOGIQUES D'APOMORPHINE ADMINISTREE ORALEMENT PAR VOIE MUQUEUSE
Publication
Application
Priority
- US 0034548 W 20001219
- US 47584499 A 19991230
Abstract (en)
[origin: WO0149292A1] A pharmaceutical formulation for the prolonged-release oral mucosal administration of apomorpine which comprises a therapeutically effective amount of apomorphine or a pharmaceutically acceptable salt or pro-drug thereof in combination with a carrier comprising from about 10 percent by weight to about 95 percent by weight dextran, based upon the total weight of the formulation. In one embodiment of the invention, dextran having a molecular weight in the range between about 5000 Daltons and 100,000 Daltons is the sole component of the formulation for prolonging the release of the active drug component. In an alternative embodiment, a mixture of microcrystalline cellulose and dextran act as the components to prolong the release of apomorphine.
IPC 1-7
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 9/22 (2006.01); C07D 221/18 (2006.01); A61K 31/473 (2006.01); A61K 47/26 (2006.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP)
A61K 9/0056 (2013.01); A61K 9/006 (2013.01); A61K 9/205 (2013.01); A61P 25/00 (2018.01); A61P 25/16 (2018.01); A61P 43/00 (2018.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0149292 A1 20010712; AU 2440901 A 20010716; BR 0012822 A 20040309; CA 2394297 A1 20010712; CN 1414853 A 20030430; CZ 20022245 A3 20021016; EP 1242088 A1 20020925; HK 1051315 A1 20030801; HU P0400495 A2 20040628; HU P0400495 A3 20070502; IL 150034 A0 20021201; JP 2004501065 A 20040115; MX PA02006034 A 20040823; NO 20023190 D0 20020701; NO 20023190 L 20020829; PL 366204 A1 20050124
DOCDB simple family (application)
US 0034548 W 20001219; AU 2440901 A 20001219; BR 0012822 A 20001219; CA 2394297 A 20001219; CN 00818098 A 20001219; CZ 20022245 A 20001219; EP 00988174 A 20001219; HK 03101912 A 20030314; HU P0400495 A 20001219; IL 15003400 A 20001219; JP 2001549660 A 20001219; MX PA02006034 A 20001219; NO 20023190 A 20020701; PL 36620400 A 20001219