Global Patent Index - EP 1242107 A1

EP 1242107 A1 2002-09-25 - METHOD FOR PR-39 PEPTIDE MEDIATED SELECTIVE INHIBITION OF IKAPPABALPHA DEGRADATION

Title (en)

METHOD FOR PR-39 PEPTIDE MEDIATED SELECTIVE INHIBITION OF IKAPPABALPHA DEGRADATION

Title (de)

VERFAHREN ZUR HERSTELLUNG VON DURCH PR-39 PEPTID VERMITTELTE SELEKTIVER HEMMUNG VON IKAPPABALOHA ABBAU

Title (fr)

PROCEDE D'INHIBITION SELECTIVE DE LA DEGRADATION DE LA PROTEINE IKAPPABALPHA INDUITE PAR LE PEPTIDE PR-39

Publication

EP 1242107 A1 (EN)

Application

EP 00989492 A

Priority

  • US 0035293 W
  • US 47496799 A

Abstract (en)

[origin: WO0147540A1] The present invention provides both a method and means for regulating I kappa B alpha degradation, NF kappa B activity, and NF kappa B-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such I kappa B alpha and proteasomes as are present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with I kappa B alpha is a selective alteration in the intracellular proteolytic activity of proteasomes, which in turn, causes a reduction of I kappa B alpha , a decrease of NF kappa B activity, and a down-regulation of NF kappa B-dependent gene expression.

IPC 1-7 (main, further and additional classification)

A61K 38/00; A61K 38/16; C07K 7/00; C07K 7/04; C07K 7/06; C07K 14/47

IPC 8 full level (invention and additional information)

C07K 14/47 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 14/4705 (2013.01); C07K 14/4723 (2013.01); A61K 38/00 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0147540 A1 20010705; AU 2599001 A 20010709; CA 2397955 A1 20010705; EP 1242107 A1 20020925; EP 1242107 A4 20041006

INPADOC legal status


2006-03-29 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20050906

2005-06-08 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20050425

2004-10-06 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20040824

2004-10-06 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 38/00 A

2004-10-06 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 38/16 B

2004-10-06 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 07K 7/00 B

2004-10-06 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 07K 7/04 B

2004-10-06 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 07K 7/06 B

2004-10-06 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 07K 14/47 B

2002-09-25 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020627

2002-09-25 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR