EP 1242107 A1 20020925 - METHOD FOR PR-39 PEPTIDE MEDIATED SELECTIVE INHIBITION OF IKAPPABALPHA DEGRADATION
Title (en)
METHOD FOR PR-39 PEPTIDE MEDIATED SELECTIVE INHIBITION OF IKAPPABALPHA DEGRADATION
Title (de)
VERFAHREN ZUR HERSTELLUNG VON DURCH PR-39 PEPTID VERMITTELTE SELEKTIVER HEMMUNG VON IKAPPABALOHA ABBAU
Title (fr)
PROCEDE D'INHIBITION SELECTIVE DE LA DEGRADATION DE LA PROTEINE IKAPPABALPHA INDUITE PAR LE PEPTIDE PR-39
Publication
Application
Priority
- US 0035293 W 20001227
- US 47496799 A 19991229
Abstract (en)
[origin: WO0147540A1] The present invention provides both a method and means for regulating I kappa B alpha degradation, NF kappa B activity, and NF kappa B-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such I kappa B alpha and proteasomes as are present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with I kappa B alpha is a selective alteration in the intracellular proteolytic activity of proteasomes, which in turn, causes a reduction of I kappa B alpha , a decrease of NF kappa B activity, and a down-regulation of NF kappa B-dependent gene expression.
IPC 1-7
A61K 38/00; A61K 38/16; C07K 7/00; C07K 7/04; C07K 7/06; C07K 14/47
IPC 8 full level
C07K 14/47 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/4705 (2013.01); C07K 14/4723 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0147540 A1 20010705; AU 2599001 A 20010709; CA 2397955 A1 20010705; EP 1242107 A1 20020925; EP 1242107 A4 20041006
DOCDB simple family (application)
US 0035293 W 20001227; AU 2599001 A 20001227; CA 2397955 A 20001227; EP 00989492 A 20001227