EP 1242124 A1 20020925 - POLYNUCLEOTIDE VACCINES EXPRESSING CODON OPTIMIZED HIV-1 POL AND MODIFIED HIV-1 POL
Title (en)
POLYNUCLEOTIDE VACCINES EXPRESSING CODON OPTIMIZED HIV-1 POL AND MODIFIED HIV-1 POL
Title (de)
POLYNUKLEOTID-IMPFSTOFFE, DIE KODON-OPTIMIERTES HIV-1 POL UND MODIFIZIERTES HIV-1 POL EXPRIMIEREN
Title (fr)
VACCINS POLYNUCLEOTIDIQUES EXPRIMANT LE GENE POL DU VIH-1 A OPTIMISATION DES CODONS ET LE GENE POL DU VIH-1 MODIFIE
Publication
Application
Priority
- US 0034724 W 20001221
- US 17154299 P 19991222
Abstract (en)
[origin: WO0145748A1] Pharmaceutical compositions which comprise HIV Pol DNA vaccines are disclosed, along with the production and use of these DNA vaccines. The pol-based DNA vaccines of the invention are administered directly introduced into living vertebrate tissue, preferably humans, and preferably express inactivated versions of the HIV Pol protein devoid of protease, reverse transcriptase activity, RNase H activity and integrase activity, inducing a cellular immune response which specifically recognizes human immunodeficiency virus-1 (HIV-1). The DNA molecules which comprise the open reading frame of these DNA vaccines are synthetic DNA molecules encoding codon optimized HIV-1 Pol and codon optimized inactive derivatives of optimized HIV-1 Pol, including DNA molecules which encode inactive Pol proteins which comprise an amino terminal leader peptide.
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); A61K 48/00 (2006.01); A61P 31/18 (2006.01); C07K 14/16 (2006.01); C12N 15/09 (2006.01)
CPC (source: EP)
A61P 31/18 (2017.12); C07K 14/005 (2013.01); A61K 2039/5256 (2013.01); C12N 2740/16222 (2013.01); C12N 2800/22 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0145748 A1 20010628; AU 2585801 A 20010703; AU 779951 B2 20050224; CA 2395429 A1 20010628; EP 1242124 A1 20020925; EP 1242124 A4 20040714; JP 2003520786 A 20030708
DOCDB simple family (application)
US 0034724 W 20001221; AU 2585801 A 20001221; CA 2395429 A 20001221; EP 00989347 A 20001221; JP 2001546687 A 20001221