Global Patent Index - EP 1242124 A1

EP 1242124 A1 2002-09-25 - POLYNUCLEOTIDE VACCINES EXPRESSING CODON OPTIMIZED HIV-1 POL AND MODIFIED HIV-1 POL

Title (en)

POLYNUCLEOTIDE VACCINES EXPRESSING CODON OPTIMIZED HIV-1 POL AND MODIFIED HIV-1 POL

Title (de)

POLYNUKLEOTID-IMPFSTOFFE, DIE KODON-OPTIMIERTES HIV-1 POL UND MODIFIZIERTES HIV-1 POL EXPRIMIEREN

Title (fr)

VACCINS POLYNUCLEOTIDIQUES EXPRIMANT LE GENE POL DU VIH-1 A OPTIMISATION DES CODONS ET LE GENE POL DU VIH-1 MODIFIE

Publication

EP 1242124 A1 (EN)

Application

EP 00989347 A

Priority

  • US 0034724 W
  • US 17154299 P

Abstract (en)

[origin: WO0145748A1] Pharmaceutical compositions which comprise HIV Pol DNA vaccines are disclosed, along with the production and use of these DNA vaccines. The pol-based DNA vaccines of the invention are administered directly introduced into living vertebrate tissue, preferably humans, and preferably express inactivated versions of the HIV Pol protein devoid of protease, reverse transcriptase activity, RNase H activity and integrase activity, inducing a cellular immune response which specifically recognizes human immunodeficiency virus-1 (HIV-1). The DNA molecules which comprise the open reading frame of these DNA vaccines are synthetic DNA molecules encoding codon optimized HIV-1 Pol and codon optimized inactive derivatives of optimized HIV-1 Pol, including DNA molecules which encode inactive Pol proteins which comprise an amino terminal leader peptide.

IPC 1-7 (main, further and additional classification)

C12N 15/85; A61K 39/21; A61K 48/00; C07K 14/16

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); A61P 31/18 (2006.01); C07K 14/16 (2006.01)

CPC (invention and additional information)

C07K 14/005 (2013.01); A61K 2039/5256 (2013.01); C12N 2740/16222 (2013.01); C12N 2800/22 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0145748 A1 20010628; AU 2585801 A 20010703; AU 779951 B2 20050224; CA 2395429 A1 20010628; EP 1242124 A1 20020925; EP 1242124 A4 20040714; JP 2003520786 A 20030708

INPADOC legal status


2008-11-19 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20080603

2004-09-08 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040726

2004-07-14 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20040528

2004-05-19 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 12N 15/85 A

2004-05-19 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 07K 14/16 B

2004-05-19 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 48/00 B

2004-05-19 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 39/21 B

2002-09-25 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020722

2002-09-25 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-25 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL PAYMENT 20020722;LT PAYMENT 20020722;LV PAYMENT 20020722;MK PAYMENT 20020722;RO PAYMENT 20020722;SI PAYMENT 20020722