Global Patent Index - EP 1242374 A1

EP 1242374 A1 2002-09-25 - ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS

Title (en)

ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS

Title (de)

ACRYLOYLPEPTIDISCHENDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ANTITUMORMITTEL

Title (fr)

DERIVES PEPTIDIQUES D'ACRYLOYLE, PROCEDE DE PREPARATION ET LEUR UTILISATION EN TANT QU'AGENTS ANTITUMORAUX

Publication

EP 1242374 A1 (EN)

Application

EP 00993255 A

Priority

  • EP 0011714 W
  • GB 9928703 A

Abstract (en)

[origin: WO0140181A1] Compounds which are acryloyl peptidic derivatives of formula (I), wherein n is 3 or 4; m is 0, 1 or 2; X and Y are the same or different and are selected, independently for each heterocyclic ring, from N or CH; R1 and R2, the same or different, are selected from hydrogen, halogen or C1-C4 alkyl; R3 is hydrogen or halogen, B is selected from the groups consisting of formulae (1), (2), (3), (4), (5), (6) and (7) wherein R4, R5, R7, and R8 are, independently from each other, hydrogen or C1-C4 alkyl; R6 is hydrogen, hydroxy or C1-C4 alkyl; or a pharmaceutically acceptable salt thereof; with the provisos that X and Y are not both N atoms for the same heterocyclic ring; when all of X and Y are CH groups and m is 0, then at least one of R4, R5, or R6 is other than hydrogen; when at least one of X and Y is other than CH, then at least one of R4 and R5 is other than hydrogen; are useful as antitumor agents.

IPC 1-7 (main, further and additional classification)

C07D 207/34; A61K 31/40; A61P 35/02; C07D 403/14

IPC 8 full level (invention and additional information)

A61K 31/40 (2006.01); A61K 31/4178 (2006.01); A61K 31/506 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C07D 207/34 (2006.01); C07D 207/416 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01)

CPC (invention and additional information)

C07D 403/12 (2013.01); C07D 207/34 (2013.01); C07D 403/14 (2013.01)

Citation (search report)

See references of WO 0140181A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0140181 A1 20010607; AU 2837001 A 20010612; AU 781657 B2 20050602; BR 0016115 A 20020820; CA 2395094 A1 20010607; EP 1242374 A1 20020925; GB 9928703 D0 20000202; JP 2003515586 A 20030507; NZ 519581 A 20040528; ZA 200204722 B 20040203

INPADOC legal status


2006-04-19 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20051012

2004-06-09 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040427

2002-12-11 [RAP3] CORRECTION OF THE ADDRESS OR NAME OF APPLICANT (A DOCUMENT)

- Owner name: PHARMACIA ITALIA S.P.A.

2002-09-25 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020612

2002-09-25 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-25 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20020612;LT PAYMENT 20020612;LV PAYMENT 20020612;MK PAYMENT 20020612;RO PAYMENT 20020612;SI PAYMENT 20020612