EP 1242374 A1 20020925 - ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS
Title (en)
ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS
Title (de)
ACRYLOYLPEPTIDISCHENDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ANTITUMORMITTEL
Title (fr)
DERIVES PEPTIDIQUES D'ACRYLOYLE, PROCEDE DE PREPARATION ET LEUR UTILISATION EN TANT QU'AGENTS ANTITUMORAUX
Publication
Application
Priority
- EP 0011714 W 20001123
- GB 9928703 A 19991203
Abstract (en)
[origin: WO0140181A1] Compounds which are acryloyl peptidic derivatives of formula (I), wherein n is 3 or 4; m is 0, 1 or 2; X and Y are the same or different and are selected, independently for each heterocyclic ring, from N or CH; R1 and R2, the same or different, are selected from hydrogen, halogen or C1-C4 alkyl; R3 is hydrogen or halogen, B is selected from the groups consisting of formulae (1), (2), (3), (4), (5), (6) and (7) wherein R4, R5, R7, and R8 are, independently from each other, hydrogen or C1-C4 alkyl; R6 is hydrogen, hydroxy or C1-C4 alkyl; or a pharmaceutically acceptable salt thereof; with the provisos that X and Y are not both N atoms for the same heterocyclic ring; when all of X and Y are CH groups and m is 0, then at least one of R4, R5, or R6 is other than hydrogen; when at least one of X and Y is other than CH, then at least one of R4 and R5 is other than hydrogen; are useful as antitumor agents.
IPC 1-7
IPC 8 full level
A61K 31/40 (2006.01); A61K 31/4178 (2006.01); A61K 31/506 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C07D 207/34 (2006.01); C07D 207/416 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01)
CPC (source: EP KR)
A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); C07D 207/34 (2013.01 - EP KR); C07D 403/12 (2013.01 - EP KR); C07D 403/14 (2013.01 - EP KR)
Citation (search report)
See references of WO 0140181A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0140181 A1 20010607; AU 2837001 A 20010612; AU 781657 B2 20050602; BR 0016115 A 20020820; CA 2395094 A1 20010607; EP 1242374 A1 20020925; GB 9928703 D0 20000202; JP 2003515586 A 20030507; KR 20020084069 A 20021104; NZ 519581 A 20040528; ZA 200204722 B 20040203
DOCDB simple family (application)
EP 0011714 W 20001123; AU 2837001 A 20001123; BR 0016115 A 20001123; CA 2395094 A 20001123; EP 00993255 A 20001123; GB 9928703 A 19991203; JP 2001541867 A 20001123; KR 20027007127 A 20020603; NZ 51958100 A 20001123; ZA 200204722 A 20020612