EP 1242394 A1 20020925 - NOVEL 3-OXO-2,1-BENZISOXAZOL-1(3H)-CARBOXAMIDES FOR TREATMENT OF CNS DISEASES
Title (en)
NOVEL 3-OXO-2,1-BENZISOXAZOL-1(3H)-CARBOXAMIDES FOR TREATMENT OF CNS DISEASES
Title (de)
NEUE 3-OXO-2,1-BENZISOXAZOL-1(3H)-CARBOXAMIDE ZUR BEHANDLUNG VON ZNS-ERKRANKUNGEN
Title (fr)
NOUVEAUX 3-OXO-2,1-BENZISOXAZOL-1(3H)-CARBOXAMIDES POUR LE TRAITEMENT DE MALADIES DU SYSTEME NERVEUX CENTRAL
Publication
Application
Priority
- DE 19960917 A 19991217
- EP 0012268 W 20001206
Abstract (en)
[origin: WO0144211A1] The invention relates to novel 3-oxo-2,1-benzisoxazol-1(3H)-carboxamides (I), where R<1>, R<2> are the same or different and independently = H, halogen, C1 C6 alkyl, C1 C6 alkoxy, C1 C3 perfluoroalkyl, or a group NR<5>R<6>; R<3>, R<4> are the same or different and independently = C1 C8 alkyl, whose carbon chain is optionally interrupted by an O, S or NR<7> and is optionally singly or severally substituted by C3 C6 cycloalkyl, C1 C4 alkoxy, OH, halogen or NR<8>R<9>; C3 C8 cycloalkyl whose carbon chain is optionally interrupted by an O, S or NR<10> and is optionally singly or severally substituted by C1 C4 alkoxy, OH, halogen or NR<11>R<12>; or R<3> and R<4> together with a nitrogen atom form a saturated or partially unsaturated 3- to 10-membered mono- or bi-cyclic heterocycle, which, optionally, contains up to two further heteroatoms, from N, O or S and is, optionally, substituted by C1 C4 alkyl, C1 C4 alkoxy, OH, halogen, COOR<13> or NR<14>R<15>and X = O or S. The invention further relates to methods for production thereof and use thereof in the production of medicaments for the prophylaxis and/or treatment of diseases of the central nervous system, in particular, cognitive disorders, such as Alzheimer's disease and other forms of dementia, cerebral infarct, skull and brain trauma and pain.
IPC 1-7
IPC 8 full level
A61K 31/423 (2006.01); A61K 31/5377 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/28 (2006.01); C07D 261/20 (2006.01); C07D 413/06 (2006.01)
CPC (source: EP US)
A61P 25/00 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/28 (2017.12 - EP); C07D 261/20 (2013.01 - EP US)
Citation (search report)
See references of WO 0144211A1
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 0144211 A1 20010621; AU 2005501 A 20010625; CA 2395167 A1 20010621; DE 19960917 A1 20010621; EP 1242394 A1 20020925; JP 2003516976 A 20030520; US 6589949 B1 20030708
DOCDB simple family (application)
EP 0012268 W 20001206; AU 2005501 A 20001206; CA 2395167 A 20001206; DE 19960917 A 19991217; EP 00983231 A 20001206; JP 2001544701 A 20001206; US 14965802 A 20021022