EP 1242441 A2 20020925 - POLYNUCLEOTIDE VACCINES EXPRESSING CODON OPTIMIZED HIV-1 NEF AND MODIFIED HIV-1 NEF
Title (en)
POLYNUCLEOTIDE VACCINES EXPRESSING CODON OPTIMIZED HIV-1 NEF AND MODIFIED HIV-1 NEF
Title (de)
KODON OPTIMIERTE HIV-1 NEF UND MODIFIZIERTES HIV-1 NEF EXPRIMIERENDE POLYNUCLEOTIDIMPFSTOFFE
Title (fr)
VACCINS POLYNUCLEOTIDIQUES EXPRIMANT LA PROTEINE NEF DE VIH-1 OPTIMISEE PAR CODONS ET PROTEINE NEF DE VIH-1 MODIFIEE
Publication
Application
Priority
- US 0034162 W 20001215
- US 17244299 P 19991217
Abstract (en)
[origin: WO0143693A2] Pharmaceutical compositions which comprise HIV Nef DNA vaccines are disclosed, along with the production and use of these DNA vaccines. The nef-based DNA vaccines of the invention are administered directly introduced into living vertebrate tissue, preferably humans, and express the HIV Nef protein or biologically relevant portions thereof, inducing a cellular immune response which specifically recognizes human immunodeficiency virus-1 (HIV-1). The DNA molecules which comprise the open reading frame of these DNA vaccines are synthetic DNA molecules encoding codon optimized HIV-1 Nef and derivatives of optimized HIV-1 Nef, including nef modifications comprising amino terminal leader peptides, removal of the amino terminal myristylation site, and/or modification of the Nef dileucine motif. These modifications may effect wild type characteristics of Nef, such as myristylation and down regulation of host CD4.
IPC 1-7
C07H 21/04; C12N 15/00; A61K 39/00; A61K 39/39; A61P 31/18; A61K 48/00; C12N 15/09; C07K 14/16
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61P 31/18 (2006.01); C07K 14/16 (2006.01)
CPC (source: EP)
A61P 31/18 (2017.12); C07K 14/005 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55511 (2013.01); A61K 2039/57 (2013.01); C12N 2740/16322 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0143693 A2 20010621; WO 0143693 A3 20020221; AU 2581001 A 20010625; AU 782193 B2 20050707; CA 2393861 A1 20010621; EP 1242441 A2 20020925; EP 1242441 A4 20040414; JP 2003516741 A 20030520
DOCDB simple family (application)
US 0034162 W 20001215; AU 2581001 A 20001215; CA 2393861 A 20001215; EP 00989282 A 20001215; JP 2001544634 A 20001215