Global Patent Index - EP 1242451 A2

EP 1242451 A2 2002-09-25 - COMPOSITIONS AND METHODS FOR INHIBITING ENDOTHELIAL CELL PROLIFERATION

Title (en)

COMPOSITIONS AND METHODS FOR INHIBITING ENDOTHELIAL CELL PROLIFERATION

Title (de)

ZUSAMMENSETZUNG UND VERFAHREN ZUR HEMMUNG DER PROLIFERATION VON ENDOTHELZELLEN

Title (fr)

COMPOSITIONS ET PROCEDES D'INHIBITION DE LA PROLIFERATION DE CELLULES ENDOTHELIALES

Publication

EP 1242451 A2 (EN)

Application

EP 00990940 A

Priority

  • US 0034039 W
  • US 17100799 P
  • US 19356600 P

Abstract (en)

[origin: WO0144294A2] Compositions and methods for regulating angiogenic activity wherein the compositions comprise proteins belonging to the family of kringle domain containing proteins and peptides and active fragments thereof are provided. More specifically, compositions and methods comprising kringle domain containing proteins and peptides such as hepatocyte growth factor (HGF) and/or macrophage stimulating protein (MSP), and biologically active fragments thereof are provided. HGF protein fragments of the present invention exhibit potent antiangiogenic activity on human and other animal cells, particularly endothelial cells. More particularly, compositions comprising HGF fragments, and/or HGF fragment homologs, may be combined with a pharmaceutically acceptable excipient or carrier and used to inhibit angiogenesis and angiogenesis-related diseases such as cancer, arthritis, macular degeneration, and diabetic retinopathy.

IPC 1-7 (main, further and additional classification)

C07K 14/52; A61K 38/18; A61K 38/19; C07K 14/475

IPC 8 full level (invention and additional information)

C12Q 1/02 (2006.01); A61K 38/00 (2006.01); A61K 38/18 (2006.01); A61K 38/22 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 7/04 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 9/14 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 17/12 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)

CPC (invention and additional information)

A61K 38/1833 (2013.01)

Citation (search report)

See references of WO 0144294A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0144294 A2 20010621; WO 0144294 A3 20020207; AU 3074801 A 20010625; AU 784359 B2 20060316; CA 2394167 A1 20010621; EP 1242451 A2 20020925; JP 2003517007 A 20030520

INPADOC legal status


2007-04-18 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20061021

2004-10-06 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040819

2002-12-18 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: LIANG, HONG

2002-12-18 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: SIM, KIM, LEE

2002-12-18 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: DEY, CLARA

2002-09-25 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020711

2002-09-25 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-09-25 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI