Global Patent Index - EP 1242611 A4

EP 1242611 A4 20040811 - COMPOSITIONS AND METHODS INVOLVING AN ESSENTIAL STAPHYLOCOCCUS AUREUS GENE AND ITS ENCODED PROTEIN

Title (en)

COMPOSITIONS AND METHODS INVOLVING AN ESSENTIAL STAPHYLOCOCCUS AUREUS GENE AND ITS ENCODED PROTEIN

Title (de)

ZUSAMMENSETZUNGEN UND VERFAHREN UNTER VERWENDUNG EINES ESSENTIELLEN STAPHYLOCOCUS AUREUS GENS UND DESSEN KODIERTEM PROTEIN

Title (fr)

COMPOSITIONS ET METHODES CONCERNANT UN GENE ESSENTIEL DE STAPHYLOCOCCUS AUREUS ET SA PROTEINE CODEE

Publication

EP 1242611 A4 20040811 (EN)

Application

EP 00991434 A 20001221

Priority

  • US 0035180 W 20001221
  • US 47051299 A 19991222
  • US 68995200 A 20001012

Abstract (en)

[origin: WO0146383A2] This invention relates to newly identified polynucleotides and polypeptides, their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a <i>Staphylococcus aureus (S. aureus)</i> DnaI related protein, as well as its variants. Also, the invention relates to a specific interaction between the <i>S. aureus</i> DnaI related protein or specific regions thereof, and a growth-inhibitory protein encoded by the <i>S. aureus</i> bacteriophage 77 genome. The phage protein interacts with amino acids 150 - 313 of <i>S. aureus</i> DnaI polypeptide, and the invention relates to the use of this interaction target site as the basis of drug screening assays. In addition, the invention relates to polynucleotides and polypeptides of a protein complex containing <i>S. aureus</i> DnaI and DnaC related proteins, as well as their variants.

IPC 1-7

C12P 21/06; G01N 33/53; C07K 14/00; C07K 16/00

IPC 8 full level

G01N 33/50 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 31/04 (2006.01); C07H 21/00 (2006.01); C07K 14/31 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/02 (2006.01); C12Q 1/18 (2006.01); C12Q 1/68 (2006.01); C12Q 1/70 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/566 (2006.01); G01N 33/569 (2006.01); A61K 39/00 (2006.01)

CPC (source: EP)

A61P 31/04 (2018.01); C07K 14/31 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01); A61K 48/00 (2013.01)

Citation (search report)

  • [PX] WO 0032825 A2 20000608 - PHAGETECH INC [CA], et al
  • [PX] DATABASE EBI [online] 2 August 2000 (2000-08-02), KIMMERLY, W.J. ET AL.: "Staphylococcus epidermis strain SR1 clone step.1049g03 genomic sequence", XP002267915, Database accession no. AF270108
  • [PX] DATABASE EBI [online] 7 August 2000 (2000-08-07), QIAN Y. ET AL.: "Staphylococcus aureus clone sabac-135, complete sequence", XP002267916, Database accession no. AC078832
  • [PX] DATABASE EBI [online] 1 October 2000 (2000-10-01), TAKAMI, H. ET AL.: "Bacillus halodurans DnaI", XP002267917, Database accession no. Q9K863
  • [X] DATABASE EBI [online] 16 March 1999 (1999-03-16), KUNSCH CA ET AL.: "Staphylococcus aureus contig SEQ ID #106", XP002267918, Database accession no. AAV74417
  • [X] DATABASE EBI [online] 13 August 1997 (1997-08-13), OGASAWARA, N. ET AL.: "Bacillus subtilis dnaB gene for initiation of chromosomal replication", XP002267919, Database accession no. X04963
  • [X] DATABASE EBI [online] 19 March 1999 (1999-03-19), KUNSCH CA ET AL.: "Enterococcus faecalis genome contig SEQ ID NO:341", XP002267920, Database accession no. AAX13278
  • [X] DATABASE EBI [online] 1 January 1988 (1988-01-01), OGASAWARA, N. ET AL.: "Bacillus subtilis DnaI", XP002267921, Database accession no. P06567
  • [A] BRUAND C ET AL: "PRIMOSOME ASSEMBLY SITE IN BACILLUS SUBTILIS", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 14, no. 11, 1995, pages 2642 - 2650, XP001018848, ISSN: 0261-4189
  • [A] DATABASE EBI [online] 27 August 1998 (1998-08-27), BLACK MT ET AL.: "DNA encoding a Staphylococcus aureus protein of unknown function", XP002268024, Database accession no. AAT83989

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0146383 A2 20010628; WO 0146383 A3 20020103; WO 0146383 A9 20020711; AU 3266201 A 20010703; AU 778782 B2 20041223; CA 2396674 A1 20010628; CA 2396674 C 20060704; EP 1242611 A2 20020925; EP 1242611 A4 20040811; JP 2003517833 A 20030603

DOCDB simple family (application)

US 0035180 W 20001221; AU 3266201 A 20001221; CA 2396674 A 20001221; EP 00991434 A 20001221; JP 2001546881 A 20001221