EP 1244622 A1 20021002 - A PROCESS FOR PREPARING TRANS-2,4-DISUBSTITUTED PIPERIDINES
Title (en)
A PROCESS FOR PREPARING TRANS-2,4-DISUBSTITUTED PIPERIDINES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON TRANS-2,4-DISUBSTITUIERTEN PIPERIDINEN
Title (fr)
PROCEDE DE PREPARATION DE PIPERIDINES TRANS-2,4-DISUBSTITUEES
Publication
Application
Priority
- US 0032428 W 20001206
- US 17272499 P 19991220
Abstract (en)
[origin: WO0146147A1] The present invention provides a process for preparing N-protected-4-substituted piperidines of formula (I) wherein Pg represents a suitable nitrogen protecting group; X represents a heterocycle, substituted heterocycle, substituted alkenyl or substituted aryl wherein the substituted heterocycle, substituted alkenyl or substituted aryl are substituted with from 1 to 3 suitable activating groups; and R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, and R<8> each independently represent an alkyl, alkenyl, cycloalkyl, aryl, substituted aryl, heterocycle, or substituted heterocycle, comprising treating a compound of formula (II) wherein the substituents are defined as above, with triethylsilane and trifluoroacetic acid.
IPC 1-7
IPC 8 full level
C07D 211/12 (2006.01); C07D 211/22 (2006.01); C07D 409/04 (2006.01)
CPC (source: EP)
C07D 211/12 (2013.01); C07D 211/22 (2013.01); C07D 409/04 (2013.01); Y02P 20/55 (2015.11)
Citation (search report)
See references of WO 0146143A1
Citation (examination)
WO 0109126 A1 20010208 - LILLY CO ELI [US], et al
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0146147 A1 20010628; WO 0146147 A8 20020606; AU 1805701 A 20010703; EP 1244622 A1 20021002; EP 1244623 A1 20021002; WO 0146143 A1 20010628
DOCDB simple family (application)
US 0032429 W 20001206; AU 1805701 A 20001206; EP 00980848 A 20001206; EP 00982251 A 20001206; US 0032428 W 20001206