EP 1244630 A1 20021002 - AMPHIPHILIC POLYAMINES, THE USE AND METHOD FOR SYNTHESIS THEREOF
Title (en)
AMPHIPHILIC POLYAMINES, THE USE AND METHOD FOR SYNTHESIS THEREOF
Title (de)
AMPHIPHILE CHINOLYLPOLYAMINE ALS TRANSFERMITTEL FÜR BIOLOGISCH AKTIVE MAKROMOLEKÜLE
Title (fr)
POLYAMINES AMPHIPHILES, LEURS UTILISATIONS ET LEUR PROCEDE DE SYNTHESE
Publication
Application
Priority
- DE 0004443 W 20001213
- DE 19960924 A 19991217
Abstract (en)
[origin: WO0144198A1] Die vorliegende Erfindung betrifft amphiphile Polyamine und deren Salze, welche befähigt sind, Biopolymere wie DNA, RNA, Antisense-Oligonukleotide, Ribozyme, Proteine und Peptide zu komplexieren und in eukaryotische Zellen einzuschleusen. Hierbei erwiesen sich Polyaminochinolin-Derivate, welche mit lipophilen Gruppen modifiziert sind, als besonders geeignete Substanzklasse. Aufgrund ihrer Eigenschaft mit biologisch aktiven Molekülen, wie zum Beispiel DNA oder RNA, Aggregate zu bilden, eignen sich diese Verbindungen insbesondere für Anwendungen in der Gentherapie, aber auch für diagnostische Zwecke.
[origin: WO0144198A1] The invention relates to amphiphilc amines and the salts thereof, which may complex with biopolymers such as DNA, RNA, anti-sense oligonucleotides, ribozymes, proteins and peptides and transfer them into eucaryotic cells. Polyaminochinoline derivatives, which are modified with lipophilic groups are a particularly suited substance class. According to the invention, due to the property of forming aggregates with biologically active molecules such as, for example, DNA or RNA, said compounds are particularly suitable for use in gene therapy and, equally, for diagnostic purposes.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 31/7105 (2006.01); A61K 31/711 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 47/22 (2006.01); A61K 47/24 (2006.01); A61K 47/26 (2006.01); A61K 47/28 (2006.01); A61K 47/34 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); C07D 215/46 (2006.01); C07J 9/00 (2006.01); C12N 15/88 (2006.01)
CPC (source: EP US)
A61K 9/1272 (2013.01 - EP US); C07D 215/46 (2013.01 - EP US); C07J 9/00 (2013.01 - EP US); C12N 15/88 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US)
Citation (search report)
See references of WO 0144198A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0144198 A1 20010621; WO 0144198 A8 20011004; AU 2830401 A 20010625; DE 19960924 A1 20010705; DE 19960924 C2 20020801; EP 1244630 A1 20021002; JP 2003516970 A 20030520; US 2003109699 A1 20030612
DOCDB simple family (application)
DE 0004443 W 20001213; AU 2830401 A 20001213; DE 19960924 A 19991217; EP 00993406 A 20001213; JP 2001544688 A 20001213; US 14973202 A 20020711