Global Patent Index - EP 1244669 A1

EP 1244669 A1 20021002 - PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS

Title (en)

PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS

Title (de)

PYRAZOLOPYRAZINE UND IHRE VERWENDUNG ALS ADENOSIN ANTAGONISTEN

Title (fr)

PYRAZOLOPYRAZINES ET LEUR UTILISATION COMME ANTAGONISTES VIS-A-VIS DE L'ADENOSINE

Publication

EP 1244669 A1 20021002 (EN)

Application

EP 00974973 A 20001113

Priority

  • AU PQ441499 A 19991202
  • JP 0008008 W 20001113

Abstract (en)

[origin: WO0140230A1] A pyrazolopyrazine compound of formula (I): wherein R<1> is aryl which may have one or more suitable substituent(s); and R<2> is hydrogen; lower alkyl; lower alkenyl; cyclo(lower)alkyl; heteromonocyclic group; lower alkyl substituted with one or more substituent(s) selected from the group consisting of cyclo(lower)alkyl, halogen, cyano, aryl and heteromonocyclic group, or a salt thereof. The pyrazolopyrazine compound (I) and salt thereof of the present invention are adenosine antagonists and are useful for the prevention and/or treatment of depression, dementia (e.g. Alhzheimer's disease, cerebrovascular dementia, dementia accompanying Parkinson's disease, etc.), Parkinson's disease, anxiety, pain, cerebrovascular disease (e.g. stroke, etc.), heart failure and the like.

IPC 1-7

C07D 487/04; A61K 31/495; A61P 25/28; A61P 25/16; A61P 25/22; A61P 9/04; A61P 1/04; A61P 1/18; A61P 13/12; A61P 9/10

IPC 8 full level

A61K 31/4985 (2006.01); A61P 1/04 (2006.01); A61P 1/18 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/02 (2006.01); A61P 9/06 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 11/06 (2006.01); A61P 13/12 (2006.01); A61P 19/06 (2006.01); A61P 25/04 (2006.01); A61P 25/16 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 37/06 (2006.01); C07D 487/04 (2006.01)

CPC (source: EP)

A61P 1/04 (2018.01); A61P 1/18 (2018.01); A61P 3/04 (2018.01); A61P 3/10 (2018.01); A61P 7/02 (2018.01); A61P 9/00 (2018.01); A61P 9/02 (2018.01); A61P 9/04 (2018.01); A61P 9/06 (2018.01); A61P 9/10 (2018.01); A61P 9/12 (2018.01); A61P 11/06 (2018.01); A61P 13/12 (2018.01); A61P 19/06 (2018.01); A61P 25/04 (2018.01); A61P 25/16 (2018.01); A61P 25/22 (2018.01); A61P 25/24 (2018.01); A61P 25/28 (2018.01); A61P 37/06 (2018.01); C07D 487/04 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0140230 A1 20010607; AR 026470 A1 20030212; AU PQ441499 A0 20000106; EP 1244669 A1 20021002; JP 2003515537 A 20030507

DOCDB simple family (application)

JP 0008008 W 20001113; AR P000106007 A 20001114; AU PQ441499 A 19991202; EP 00974973 A 20001113; JP 2001540985 A 20001113