EP 1244773 A1 20021002 - MUTATED HEPATITIS B VIRUS, ITS NUCLEIC AND PROTEIN CONSTITUENTS AND USES THEREOF
Title (en)
MUTATED HEPATITIS B VIRUS, ITS NUCLEIC AND PROTEIN CONSTITUENTS AND USES THEREOF
Title (de)
MUTIERTES HEPATITIS B VIRUS, DESSEN NUKLEINSÄURE UND PROTEINE UND DEREN ANWENDUNGEN
Title (fr)
VIRUS MUTE DE L'HEPATITE B, SES CONSTINUANTS NUCLEIQUES ET PROTEIQUES ET LEURS APPLICATIONS
Publication
Application
Priority
- FR 0100038 W 20010105
- FR 0000129 A 20000106
Abstract (en)
[origin: WO0149828A1] The invention concerns an isolated mHBV having the following characteristics: (i) a genome with partly double-strand circular DNA, (ii) said genome including the Pre-S, S, C, P and X genes, (iii) the Pre-S genes coding for surface antigens, the S gene coding for a HBsAg envelope protein, the C gene coding for a HBeAg protein and aHBcAg protein, the P gene coding for a DNA reverse polymerase/transcriptase enzyme and the X gene coding for a HBxAg protein. The invention is characterised in that the gene S comprises a DNA nucleotide sequence referenced SEQ ID NO 1 and the Pre-S gene comprises a nucleotide sequence referenced SED ID NO 3. The invention also concerns DNA molecule, RNA molecule, modified surface proteins and their uses in particular for diagnostic, therapeutic and vaccine purposes.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); A61K 31/7088 (2006.01); A61K 35/76 (2015.01); A61K 38/00 (2006.01); A61K 38/16 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 1/16 (2006.01); A61P 31/20 (2006.01); C07K 14/02 (2006.01); C07K 16/08 (2006.01); C12N 1/19 (2006.01); C12N 5/02 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 7/01 (2006.01); C12N 15/09 (2006.01); C12N 15/36 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/566 (2006.01); G01N 33/576 (2006.01); C12R 1/865 (2006.01); C12R 1/91 (2006.01); C12R 1/93 (2006.01)
CPC (source: EP US)
A61P 1/16 (2018.01 - EP); A61P 31/20 (2018.01 - EP); C07K 14/005 (2013.01 - EP US); C12N 7/00 (2013.01 - EP US); A61K 39/00 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C12N 2730/10122 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0149828 A1 20010712; AU 3184701 A 20010716; BR 0107457 A 20030211; EP 1244773 A1 20021002; FR 2803599 A1 20010713; FR 2803599 B1 20041119; JP 2003519477 A 20030624; US 2003129202 A1 20030710
DOCDB simple family (application)
FR 0100038 W 20010105; AU 3184701 A 20010105; BR 0107457 A 20010105; EP 01903881 A 20010105; FR 0000129 A 20000106; JP 2001550357 A 20010105; US 16966802 A 20021216