EP 1245679 A1 20021002 - VACCINE STRAINS AGAINST INFECTION WITH PATHOGENIC BACTERIA
Title (en)
VACCINE STRAINS AGAINST INFECTION WITH PATHOGENIC BACTERIA
Title (de)
IMPFSTÄMME GEGEN INFEKTIONEN MIT PATHOGENEN BAKTERIEN
Title (fr)
SOUCHES DE VACCIN CONTRE DES INFECTIONS A BACTERIES PATHOGENES
Publication
Application
Priority
- JP 0003990 W 20000619
- JP 36301299 A 19991221
Abstract (en)
An object of the present invention is to provide a vaccine strain which is extremely safe and has potent antigenicity (immunogenicity), and therefore, can be used as an effective live vaccine against infection with various pathogenic bacteria, and a live vaccine component containing the vaccine strain. For preparation of a vaccine strain against infection with pathogenic bacteria having a double gene mutation and comprised of pathogenic bacteria whose pathogenicity-expressing function is deficient or deteriorated, DNA wherein a mukFEB operon that relates to temperature sensitivity in colony formation has been substituted with a kanamycin-resistant gene is introduced by homologous recombination into a deletion strain of a DNA adenine methylase gene that relates to pathogenicity-expressing function of pathogenic bacteria including pathogenic Escherichia coli, Salmonella typhimurium, Salmonella typhi, Salmonella typhosa, Shigella, Klebsiella, Haemophilus influenzae, Pasteurella and Actinobacillus.
IPC 1-7
C12N 15/52; C12N 1/21; A61K 39/02; A61K 39/108; A61K 39/112; A61K 39/102
IPC 8 full level
C07K 14/245 (2006.01)
CPC (source: EP)
A61K 39/0258 (2013.01); C07K 14/245 (2013.01); A61K 2039/522 (2013.01); Y02A 50/30 (2017.12)
Designated contracting state (EPC)
CH ES FR GB LI SE
DOCDB simple family (publication)
EP 1245679 A1 20021002; EP 1245679 A4 20050316; WO 0146428 A1 20010628
DOCDB simple family (application)
EP 00937302 A 20000619; JP 0003990 W 20000619