EP 1246847 A2 20021009 - DNA ENCODING A HUMAN MELANIN CONCENTRATING HORMONE RECEPTOR (MCH1) AND USES THEREOF
Title (en)
DNA ENCODING A HUMAN MELANIN CONCENTRATING HORMONE RECEPTOR (MCH1) AND USES THEREOF
Title (de)
FüR EINEN HUMANEN MELANIN-KONZENTRIERENDEN REZEPTOR (MCH1) KODIERENDE DNS UND DEREN VERWENDUNGEN
Title (fr)
ADN CODANT POUR UN RECEPTEUR HUMAIN DE L'HORMONE DE CONCENTRATION DE LA MELANINE (MCH1) ET SES APPLICATIONS
Publication
Application
Priority
- US 0121350 W 20010705
- US 61063500 A 20000705
Abstract (en)
[origin: WO0202744A2] This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequence of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors. This invention provides a method of modifying the feeding behavior of a subject which comprises administering to the subject an amount of an MCH1 antagonist effective to decrease the body mass of the subject and/or decrease the consumption of food by the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of an MCH1 antagonist effective to treat the subject's depression and/or anxiety.
IPC 1-7
C07K 14/72; C07H 21/04; C12N 15/63; C12N 5/06; C12N 5/08; C12N 5/10; G01N 33/53; A61K 38/00; C12P 21/02
IPC 8 full level
A01K 67/027 (2006.01); A61K 31/165 (2006.01); A61K 31/4192 (2006.01); A61K 31/437 (2006.01); A61K 31/438 (2006.01); A61K 31/445 (2006.01); A61K 31/4468 (2006.01); A61K 31/4709 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/7088 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 1/00 (2006.01); A61P 3/10 (2006.01); A61P 3/12 (2006.01); A61P 5/00 (2006.01); A61P 5/06 (2006.01); A61P 5/38 (2006.01); A61P 9/12 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 15/00 (2006.01); A61P 19/00 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 25/04 (2006.01); A61P 25/14 (2006.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 25/36 (2006.01); A61P 37/00 (2006.01); C07D 211/52 (2006.01); C07D 211/58 (2006.01); C07D 239/36 (2006.01); C07D 249/18 (2006.01); C07D 295/02 (2006.01); C07D 295/10 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 491/048 (2006.01); C07D 491/107 (2006.01); C07K 14/72 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); C40B 30/04 (2006.01); C40B 40/02 (2006.01); C40B 40/04 (2006.01); C40B 50/06 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 3/10 (2017.12); A61P 3/12 (2017.12); A61P 5/00 (2017.12); A61P 5/06 (2017.12); A61P 5/38 (2017.12); A61P 9/12 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 15/00 (2017.12); A61P 19/00 (2017.12); A61P 21/00 (2017.12); A61P 25/00 (2017.12); A61P 25/02 (2017.12); A61P 25/04 (2017.12); A61P 25/14 (2017.12); A61P 25/18 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 25/30 (2017.12); A61P 25/36 (2017.12); A61P 37/00 (2017.12); C07K 14/72 (2013.01)
Citation (search report)
See references of WO 0202744A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0202744 A2 20020110; WO 0202744 A3 20020808; AU 7320701 A 20020114; CA 2384358 A1 20020110; EP 1246847 A2 20021009; JP 2004502423 A 20040129
DOCDB simple family (application)
US 0121350 W 20010705; AU 7320701 A 20010705; CA 2384358 A 20010705; EP 01952456 A 20010705; JP 2002507986 A 20010705