EP 1246915 A2 20021009 - IMPROVED LYSOSOMAL ENZYMES AND LYSOSOMAL ENZYME ACTIVATORS
Title (en)
IMPROVED LYSOSOMAL ENZYMES AND LYSOSOMAL ENZYME ACTIVATORS
Title (de)
VERBESSERTE LYSOSOMALE ENZYME UND LYSOSOMALE ENZYMAKTIVATOREN
Title (fr)
ENZYMES LYSOSOMALES AMELIOREES ET ACTIVATEURS D'ENZYMES LYSOSOMALES
Publication
Application
Priority
- DK 0000743 W 20001229
- DK PA199901891 A 19991230
- DK PA200000865 A 20000602
- DK PA200000866 A 20000602
- DK PA200001027 A 20000630
Abstract (en)
[origin: WO0149830A2] A polypeptide selected from the group of lysosomal enzymes and lysosomal enzyme activators, comprising at least one introduced glycosylation site as compared to a corresponding parent enzyme or activator. By introducing additional glycosylation sites the resulting glycosylated lysosomal enzyme or activator obtains improved <i>in vivo</i> activity and thereby provides for improved treatment of lysosomal storage diseases.
IPC 1-7
IPC 8 full level
A61K 38/24 (2006.01); C12N 9/24 (2006.01); C12P 21/00 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 38/24 (2013.01); C12N 9/2402 (2013.01); C12N 9/2465 (2013.01); C12P 21/005 (2013.01); C12Y 302/01018 (2013.01); C12Y 302/0102 (2013.01); C12Y 302/01022 (2013.01); C12Y 302/01045 (2013.01); C12Y 302/01046 (2013.01); C12Y 302/01052 (2013.01); C12Y 302/01076 (2013.01); C07K 2319/00 (2013.01); Y02A 90/10 (2017.12)
Citation (search report)
See references of WO 0149830A2
Citation (examination)
- RAJALAKSHMI ET AL.: "L273S missense substitution in human lysosomal acid lipase creates a new N-glycosylation site", FEBS LETTERS, vol. 397, 1996, pages 79 - 82
- LINGEMAN ET AL.: "Effect of carbohydrate position on lysosomal trasnport of procathepsin L", MOLECULAR BIOLOGY OF THE CELL, vol. 9, May 1998 (1998-05-01), pages 1135 - 1147
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0149830 A2 20010712; WO 0149830 A3 20020207; WO 0149830 A9 20021107; AU 2352201 A 20010716; EP 1246915 A2 20021009; IL 150314 A0 20021201
DOCDB simple family (application)
DK 0000743 W 20001229; AU 2352201 A 20001229; EP 00987208 A 20001229; IL 15031400 A 20001229