Global Patent Index - EP 1246940 A2

EP 1246940 A2 20021009 - CHEMOTHERAPEUTANT SCREENING METHOD

Title (en)

CHEMOTHERAPEUTANT SCREENING METHOD

Title (de)

SCREENINGVERFAHREN FÜR CHEMOTHERAPEUTIKA

Title (fr)

PROCEDE DE CRIBLAGE POUR SUBSTANCES CHIMIOTHERAPEUTIQUES

Publication

EP 1246940 A2 20021009 (DE)

Application

EP 00991118 A 20001222

Priority

  • DE 0004643 W 20001222
  • DE 19962828 A 19991223

Abstract (en)

[origin: WO0148238A2] Disclosed is a method for determining whether a test compound is effective for a chemotherapy.The inventive method comprises the following steps: a) a DNA sequence is provided, whereby said sequence comprises site AP-1 represented in figure 5A as a constituent of a promoter, preferably promoter CD95L, which is functionally linked to a reporter gene or the CD95L gene, b) the DNA sequence a) is brought into contact with the test compound in a cellular assay, and c) activation of the promoter is determined, said activation indicating that the test compound is effective for a chemotherapy.

IPC 1-7

C12Q 1/68; G01N 33/50

IPC 8 full level

G01N 33/50 (2006.01); A61K 31/513 (2006.01); A61K 45/00 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6886 (2018.01); G01N 33/15 (2006.01)

CPC (source: EP US)

A61P 35/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12Q 1/6886 (2013.01 - EP US); C12Q 2600/136 (2013.01 - EP US)

Citation (search report)

See references of WO 0148238A2

Citation (examination)

  • HOLTZ-HEPPELMANN ET AL.: "Transcriptional regulation of the human FasL promoter-enhancer region", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 8, 1998, pages 4416 - 4423
  • HOLTZ-HEPPELMANN ET AL: "Transcriptional regulation of the human FasL promoter-enhancer region", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 8, 1998, pages 4416 - 4423

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0148238 A2 20010705; WO 0148238 A3 20020808; AU 3151601 A 20010709; CA 2395524 A1 20010705; DE 19962828 A1 20010712; EP 1246940 A2 20021009; JP 2003518389 A 20030610; US 2003157502 A1 20030821

DOCDB simple family (application)

DE 0004643 W 20001222; AU 3151601 A 20001222; CA 2395524 A 20001222; DE 19962828 A 19991223; EP 00991118 A 20001222; JP 2001548750 A 20001222; US 16905902 A 20021118