EP 1246940 A2 20021009 - CHEMOTHERAPEUTANT SCREENING METHOD
Title (en)
CHEMOTHERAPEUTANT SCREENING METHOD
Title (de)
SCREENINGVERFAHREN FÜR CHEMOTHERAPEUTIKA
Title (fr)
PROCEDE DE CRIBLAGE POUR SUBSTANCES CHIMIOTHERAPEUTIQUES
Publication
Application
Priority
- DE 0004643 W 20001222
- DE 19962828 A 19991223
Abstract (en)
[origin: WO0148238A2] Disclosed is a method for determining whether a test compound is effective for a chemotherapy.The inventive method comprises the following steps: a) a DNA sequence is provided, whereby said sequence comprises site AP-1 represented in figure 5A as a constituent of a promoter, preferably promoter CD95L, which is functionally linked to a reporter gene or the CD95L gene, b) the DNA sequence a) is brought into contact with the test compound in a cellular assay, and c) activation of the promoter is determined, said activation indicating that the test compound is effective for a chemotherapy.
IPC 1-7
IPC 8 full level
G01N 33/50 (2006.01); A61K 31/513 (2006.01); A61K 45/00 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6886 (2018.01); G01N 33/15 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12Q 1/6886 (2013.01 - EP US); C12Q 2600/136 (2013.01 - EP US)
Citation (search report)
See references of WO 0148238A2
Citation (examination)
- HOLTZ-HEPPELMANN ET AL.: "Transcriptional regulation of the human FasL promoter-enhancer region", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 8, 1998, pages 4416 - 4423
- HOLTZ-HEPPELMANN ET AL: "Transcriptional regulation of the human FasL promoter-enhancer region", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 8, 1998, pages 4416 - 4423
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0148238 A2 20010705; WO 0148238 A3 20020808; AU 3151601 A 20010709; CA 2395524 A1 20010705; DE 19962828 A1 20010712; EP 1246940 A2 20021009; JP 2003518389 A 20030610; US 2003157502 A1 20030821
DOCDB simple family (application)
DE 0004643 W 20001222; AU 3151601 A 20001222; CA 2395524 A 20001222; DE 19962828 A 19991223; EP 00991118 A 20001222; JP 2001548750 A 20001222; US 16905902 A 20021118