EP 1251849 A1 20021030 - GYRASE INHIBITORS AND USES THEREOF
Title (en)
GYRASE INHIBITORS AND USES THEREOF
Title (de)
GYRASE-INHIBITOREN UND IHRE VERWENDUNG
Title (fr)
INHIBITEURS DE LA GYRASE ET UTILISATIONS DE CES DERNIERS
Publication
Application
Priority
- US 0101377 W 20010116
- US 17667500 P 20000118
- US 25433100 P 20001208
Abstract (en)
[origin: WO0152846A1] Disclosed herein are compounds comprising the pharmacophore features HBA, HBD, Grpl, and at least two features selected from Grp2, Grp3 or Grp4 in which HBA is a hydrogen bond acceptor, HBD is a hydrogen bond donor, and Grps 1-4 are as described in the specification. The compounds are inhibitors of bacterial DNA gyrase and are useful in treating bacterial infections. The pharmacophore features may be used to identify and design new inhibitors.
IPC 1-7
A61K 31/4155; A61K 31/421; A61K 31/422; A61K 31/427; A61P 31/04
IPC 8 full level
A61K 31/4155 (2006.01); A61K 31/421 (2006.01); A61K 31/422 (2006.01); A61K 31/427 (2006.01); A61P 31/04 (2006.01); C12Q 1/25 (2006.01); G16B 15/20 (2019.01)
CPC (source: EP US)
A61K 31/4155 (2013.01 - EP); A61K 31/421 (2013.01 - EP); A61K 31/422 (2013.01 - EP); A61K 31/427 (2013.01 - EP); A61P 31/04 (2017.12 - EP); C12Q 1/25 (2013.01 - EP US); G16B 15/00 (2019.01 - EP); G16B 15/20 (2019.01 - EP US); G16B 20/00 (2019.01 - EP); Y02A 50/30 (2017.12 - EP)
Citation (search report)
See references of WO 0152846A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0152846 A1 20010726; AU 3280901 A 20010731; EP 1251849 A1 20021030
DOCDB simple family (application)
US 0101377 W 20010116; AU 3280901 A 20010116; EP 01904871 A 20010116