EP 1252164 B1 20040324 - METHOD FOR PRODUCING 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE-5-YL ACETIC ACID
Title (en)
METHOD FOR PRODUCING 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE-5-YL ACETIC ACID
Title (de)
VERFAHREN ZUR HERSTELLUNG VON 6-(4-CHLORPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL-ESSIGSÄURE
Title (fr)
PROCEDE DE PREPARATION D'ACIDE 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL-ACETIQUE
Publication
Application
Priority
MX PA00001047 A 20000128
Abstract (en)
[origin: WO0155149A1] The invention relates to a method for producing the compound of formula (I), by reacting the compound of formula (III) with oxalyl chloride and treating the product obtained with hydrazine and an alkali metal hydroxide in the aqueous phase at elevated temperatures. Once the treatment is terminated, a 3-phase system is established by adding an ether, and the compound of formula (I) is obtained by acidifying the middle phase. The invention further relates in to a polymorphous form of the compound of formula (I).
IPC 1-7
IPC 8 full level
A61K 31/407 (2006.01); A61P 3/06 (2006.01); A61P 7/02 (2006.01); A61P 11/08 (2006.01); A61P 17/00 (2006.01); A61P 17/04 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 35/04 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP KR US)
A61P 3/06 (2018.01 - EP); A61P 7/02 (2018.01 - EP); A61P 11/08 (2018.01 - EP); A61P 17/00 (2018.01 - EP); A61P 17/04 (2018.01 - EP); A61P 17/06 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 21/00 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 35/04 (2018.01 - EP); A61P 37/08 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 487/04 (2013.01 - EP KR US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0155149 A1 20010802; AT E262529 T1 20040415; AU 3371101 A 20010807; AU 779616 B2 20050203; BG 106951 A 20030731; BG 65567 B1 20081230; BR 0107898 A 20021105; CA 2397767 A1 20010802; CA 2397767 C 20080506; CN 1160357 C 20040804; CN 1396922 A 20030212; CU 23193 A3 20070323; DE 50101761 D1 20040429; DK 1252164 T3 20040705; EA 004938 B1 20041028; EA 200200740 A1 20021226; EE 05125 B1 20090216; EE 200200417 A 20031215; EP 1252164 A1 20021030; EP 1252164 B1 20040324; ES 2218382 T3 20041116; GE P20043408 B 20040610; HK 1047590 A1 20030228; HR P20020707 A2 20041231; HR P20020707 B1 20060531; HU P0300604 A2 20030728; HU P0300604 A3 20031028; IS 2404 B 20080915; IS 6475 A 20020719; JP 2004517799 A 20040617; JP 5143326 B2 20130213; KR 100749222 B1 20070813; KR 20020075895 A 20021007; NZ 520429 A 20030829; PL 208027 B1 20110331; PL 356774 A1 20040712; PT 1252164 E 20040831; RS 50374 B 20091110; SK 10432002 A3 20030204; SK 286608 B6 20090205; TR 200400691 T4 20041122; TW I289561 B 20071111; UA 72580 C2 20050315; US 2002028953 A1 20020307; US 6417371 B1 20020709; YU 56502 A 20050610; ZA 200206832 B 20031007
DOCDB simple family (application)
EP 0100852 W 20010126; AT 01905691 T 20010126; AU 3371101 A 20010126; BG 10695102 A 20020724; BR 0107898 A 20010126; CA 2397767 A 20010126; CN 01804235 A 20010126; CU 20020150 A 20020717; DE 50101761 T 20010126; DK 01905691 T 20010126; EA 200200740 A 20010126; EE P200200417 A 20010126; EP 01905691 A 20010126; ES 01905691 T 20010126; GE AP2001004919 A 20010126; HK 02109153 A 20021217; HR P20020707 A 20020828; HU P0300604 A 20010126; IS 6475 A 20020719; JP 2001561008 A 20010126; KR 20027009706 A 20020727; NZ 52042901 A 20010126; PL 35677401 A 20010126; PT 01905691 T 20010126; SK 10432002 A 20010126; TR 200400691 T 20010126; TW 90111072 A 20010509; UA 2002086986 A 20010126; US 76974201 A 20010126; YU P56502 A 20010126; ZA 200206832 A 20020827