EP 1253948 A2 20021106 - GENE THERAPY FOR TREATING OCULAR-RELATED DISORDERS
Title (en)
GENE THERAPY FOR TREATING OCULAR-RELATED DISORDERS
Title (de)
GENTHERAPIE ZUR BEHANDLUNG VON AUGENBESCHWERDEN
Title (fr)
MATIERES ET PROCEDES DESTINES AU TRAITEMENT DE TROUBLES OCULAIRES
Publication
Application
Priority
- US 0104203 W 20010209
- US 18174300 P 20000211
- US 59999700 A 20000623
- US 22833700 P 20000828
Abstract (en)
[origin: WO0158494A2] The present invention is directed to a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder, e.g., ocular neovascularization or age-related macular degeneration. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and the same or different nucleic acid sequence encoding a neurotrophic agent. The method also can comprise contacting an ocular cell with different expression vectors, each comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a nucleic acid sequence encoding a neurotrophic agent. In addition, the present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); A61P 27/02 (2006.01); C07K 14/71 (2006.01); C07K 14/81 (2006.01); C12N 15/861 (2006.01)
CPC (source: EP)
A61K 48/005 (2013.01); A61K 48/0075 (2013.01); A61P 27/02 (2017.12); C07K 14/71 (2013.01); C07K 14/811 (2013.01); C12N 15/86 (2013.01); C12N 2710/10343 (2013.01)
Citation (search report)
See references of WO 0158494A2
Citation (examination)
- WEI_YONG SHEN ET AL: "Combined Effect of Cyclosporine and Sirolimus on Improving the Longevity of Recombinant Adenovirus_mediated Transgene expression in the Retina", ARCH. OPHTHALMOLY, vol. 119, July 2001 (2001-07-01), pages 1033 - 1043, XP009187640
- REICHEL M.B. ET AL: "Immune responses limit adenovirally mediated gene expression in teh adult mouse eye", GENE THERAPY, vol. 5, no. 8, August 1998 (1998-08-01), pages 1038 - 1046, XP002981956, DOI: doi:10.1038/sj.gt.3300691
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0158494 A2 20010816; WO 0158494 A3 20020404; AU 3681801 A 20010820; AU 780634 B2 20050407; AU 780634 C 20060223; CA 2398571 A1 20010816; EP 1253948 A2 20021106; JP 2003522160 A 20030722
DOCDB simple family (application)
US 0104203 W 20010209; AU 3681801 A 20010209; CA 2398571 A 20010209; EP 01909022 A 20010209; JP 2001557602 A 20010209