Global Patent Index - EP 1253948 A2

EP 1253948 A2 2002-11-06 - GENE THERAPY FOR TREATING OCULAR-RELATED DISORDERS

Title (en)

GENE THERAPY FOR TREATING OCULAR-RELATED DISORDERS

Title (de)

GENTHERAPIE ZUR BEHANDLUNG VON AUGENBESCHWERDEN

Title (fr)

MATIERES ET PROCEDES DESTINES AU TRAITEMENT DE TROUBLES OCULAIRES

Publication

EP 1253948 A2 (EN)

Application

EP 01909022 A

Priority

  • US 0104203 W
  • US 18174300 P
  • US 59999700 A
  • US 22833700 P

Abstract (en)

[origin: WO0158494A2] The present invention is directed to a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder, e.g., ocular neovascularization or age-related macular degeneration. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and the same or different nucleic acid sequence encoding a neurotrophic agent. The method also can comprise contacting an ocular cell with different expression vectors, each comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a nucleic acid sequence encoding a neurotrophic agent. In addition, the present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof.

IPC 1-7 (main, further and additional classification)

A61K 48/00

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); A61P 27/02 (2006.01); C07K 14/71 (2006.01); C07K 14/81 (2006.01); C12N 15/861 (2006.01)

CPC (invention and additional information)

A61K 48/0075 (2013.01); A61K 48/005 (2013.01); C07K 14/71 (2013.01); C07K 14/811 (2013.01); C12N 15/86 (2013.01); C12N 2710/10343 (2013.01)

Citation (search report)

See references of WO 0158494A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0158494 A2 20010816; WO 0158494 A3 20020404; AU 3681801 A 20010820; AU 780634 B2 20050407; AU 780634 C 20060223; CA 2398571 A1 20010816; EP 1253948 A2 20021106; JP 2003522160 A 20030722

INPADOC legal status


2010-02-24 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20090901

2006-11-29 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030721

2003-09-03 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030721

2002-11-06 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020816

2002-11-06 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-06 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL;LT;LV;MK;RO;SI