EP 1254113 A1 20021106 - N-SUBSTITUTED 2-CYANOPYROLES AND -PYRROLINES WHICH ARE INHIBITORS OF THE ENZYME DPP-IV

Title (en)

N-SUBSTITUTED 2-CYANOPYROLES AND -PYRROLINES WHICH ARE INHIBITORS OF THE ENZYME DPP-IV

Title (de)

N-SUBSTITUIERTE 2-CYANOPYRROLE UND -PYRROLINE DIE INHIBITOREN DES ENZYMS DDP-IVSIND

Title (fr)

2-CYANOPYROLES ET -PYRROLINES A SUBSTITUTION N INHIBANT L'ENZYME DPP-IV

Publication

EP 1254113 A1 20021106 (EN)

Application

EP 01946849 A 20010122

Priority

DK 0100045 W 20010122
DK PA200000112 A 20000124
DK PA200000983 A 20000623

Abstract (en)

[origin: WO0155105A1] The present invention relates to new therapeutically active and selective inhibitors of the enzyme DPP-IV. Novel 2-substituted unsaturated heterocyclic compounds are provided, wherein a nitrogen atom in the heterocyclic ring is attached via an amide bond or a peptide bond to an amino acid or an amino acid derivative. These compounds are potent and selective inhibitors of DPP-IV, and are effective in treating conditions that may be regulated or normalised via inhibition of DPP-IV.

IPC 1-7

C07D 207/22; C07D 207/34; C07D 401/12; C07D 403/12; C07K 5/00; A61K 31/435; A61K 31/40; A61P 5/50

IPC 8 full level

A61K 31/00 (2006.01); A61K 31/40 (2006.01); A61K 31/427 (2006.01); A61K 31/44 (2006.01); A61K 31/4439 (2006.01); A61K 38/55 (2006.01); A61P 1/04 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 5/50 (2006.01); A61P 43/00 (2006.01); C07D 207/16 (2006.01); C07D 207/22 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 417/06 (2006.01)

CPC (source: EP)

A61K 31/00 (2013.01); A61K 31/40 (2013.01); A61K 31/44 (2013.01); A61K 31/4439 (2013.01); A61K 38/55 (2013.01); A61P 1/04 (2017.12); A61P 3/04 (2017.12); A61P 3/10 (2017.12); A61P 5/50 (2017.12); A61P 43/00 (2017.12); C07D 207/16 (2013.01); C07D 207/22 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/06 (2013.01); C07D 417/06 (2013.01)

Citation (search report)

See references of WO 0155105A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0155105 A1 20010802; AU 2830901 A 20010807; EP 1254113 A1 20021106; JP 2003520849 A 20030708

DOCDB simple family (application)

DK 0100045 W 20010122; AU 2830901 A 20010122; EP 01946849 A 20010122; JP 2001555047 A 20010122