Global Patent Index - EP 1254113 A1

EP 1254113 A1 2002-11-06 - N-SUBSTITUTED 2-CYANOPYROLES AND -PYRROLINES WHICH ARE INHIBITORS OF THE ENZYME DPP-IV

Title (en)

N-SUBSTITUTED 2-CYANOPYROLES AND -PYRROLINES WHICH ARE INHIBITORS OF THE ENZYME DPP-IV

Title (de)

N-SUBSTITUIERTE 2-CYANOPYRROLE UND -PYRROLINE DIE INHIBITOREN DES ENZYMS DDP-IVSIND

Title (fr)

2-CYANOPYROLES ET -PYRROLINES A SUBSTITUTION N INHIBANT L'ENZYME DPP-IV

Publication

EP 1254113 A1 (EN)

Application

EP 01946849 A

Priority

  • DK 0100045 W
  • DK PA200000112 A
  • DK PA200000983 A

Abstract (en)

[origin: WO0155105A1] The present invention relates to new therapeutically active and selective inhibitors of the enzyme DPP-IV. Novel 2-substituted unsaturated heterocyclic compounds are provided, wherein a nitrogen atom in the heterocyclic ring is attached via an amide bond or a peptide bond to an amino acid or an amino acid derivative. These compounds are potent and selective inhibitors of DPP-IV, and are effective in treating conditions that may be regulated or normalised via inhibition of DPP-IV.

IPC 1-7 (main, further and additional classification)

C07D 207/22; C07D 207/34; C07D 401/12; C07D 403/12; C07K 5/00; A61K 31/435; A61K 31/40; A61P 5/50

IPC 8 full level (invention and additional information)

A61K 31/00 (2006.01); A61K 31/40 (2006.01); A61K 31/427 (2006.01); A61K 31/44 (2006.01); A61K 31/4439 (2006.01); A61K 38/55 (2006.01); A61P 1/04 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 5/50 (2006.01); A61P 43/00 (2006.01); C07D 207/16 (2006.01); C07D 207/22 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 417/06 (2006.01)

CPC (invention and additional information)

C07D 401/06 (2013.01); A61K 31/00 (2013.01); A61K 31/40 (2013.01); A61K 31/44 (2013.01); A61K 31/4439 (2013.01); A61K 38/55 (2013.01); C07D 207/16 (2013.01); C07D 207/22 (2013.01); C07D 401/12 (2013.01); C07D 403/06 (2013.01); C07D 417/06 (2013.01)

Combination set (CPC)

A61K 38/55 + A61K 2300/00

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0155105 A1 20010802; AU 2830901 A 20010807; EP 1254113 A1 20021106; JP 2003520849 A 20030708

INPADOC legal status


2005-01-26 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040721

2004-04-28 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040311

2002-11-06 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020826

2002-11-06 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-06 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL;LT;LV;MK;RO;SI