EP 1254137 A1 20021106 - PYRIDO 2,3-d PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
Title (en)
PYRIDO 2,3-d PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
Title (de)
2,7-DIAMINE PYRIDO(2,3-D)PYRIMIDIN KINASE INHIBITOR
Title (fr)
INHIBITEURS DE PYRIDO 2,3-D PYRIMIDINE-2,7-DIAMINE KINASE
Publication
Application
Priority
- IB 0100069 W 20010123
- US 17826100 P 20000125
Abstract (en)
[origin: WO0155147A1] Disclosed are compounds of the formula (I) wherein: R<2>, R<7>, R<13>, R<14> and R15 are independently hydrogen, or (un)substituted lower alkyl, (un)substitued lower alkenyl, (un)substituted lower alkynyl, or (un)substituted -(CH2)nR<12>; R<5> is halogen, cyano, nitro, -R<9>, -NR<9>R<10>, or -OR<9>; R<6> is halogen, cyano, nitro, -R<9>, -NR<9>R<10>, -OR<9>, -Co2R<9>, -COR<9>, -CONR<9>R<10>, -NR<9>COR<10>, (un)substituted lower alkenyl, or (un)substituted lower alkynyl; R<8> is -CO2R<13>, -COR<13>, -CONR<13>R<14>, -CSNR<13>R<14>, -C(NR<13>)NR<14>R<15>, -SO3R<13>, -S02R<13>, -SO2NR<13>R<14>, -PO3R<13>R<14>, -POR<13>R<14>, -PO(NR<13>R<14>)2; R<9> and R<10> are independently hydrogen or (un)substituted lower alkyl; R<11> is a heteroaryl or a heterocyclic group; R<12> is a cycloalkyl, a heterocyclic, an aryl, or a heteroaryl group; and n is 0,1,2, or 3. These compounds and their pharmaceutical compositions are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cdks and growth factor-mediated kinases.
IPC 1-7
IPC 8 full level
A61K 31/305 (2006.01); A61K 31/519 (2006.01); A61P 9/10 (2006.01); A61P 17/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01); C07F 9/6561 (2006.01)
CPC (source: EP KR)
A61P 9/10 (2018.01 - EP); A61P 17/06 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 471/04 (2013.01 - EP KR); C07F 9/6561 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
WO 0155147 A1 20010802; AP 2002002586 A0 20020930; AR 030044 A1 20030813; AU 2542501 A 20010807; BG 106850 A 20030228; BR 0107751 A 20021112; CA 2397961 A1 20010802; CA 2397961 C 20080826; CN 1395578 A 20030205; CO 5261549 A1 20030331; CR 6706 A 20050404; CZ 20022475 A3 20030312; DZ 3266 A1 20010802; EA 200200643 A1 20021226; EE 200200405 A 20031215; EP 1254137 A1 20021106; GT 200100016 A 20011019; HN 2001000013 A 20010618; HU P0204141 A2 20030428; HU P0204141 A3 20050329; IL 150545 A0 20030212; IS 6443 A 20020625; JP 2003523357 A 20030805; JP 4047010 B2 20080213; KR 20020065939 A 20020814; MA 26868 A1 20041220; MX PA02007221 A 20021129; NO 20023527 D0 20020724; NO 20023527 L 20020910; OA 12161 A 20060508; PA 8510701 A1 20021211; PE 20011066 A1 20011022; PL 356802 A1 20040712; SK 10632002 A3 20030603; SV 2002000294 A 20020716; TN SN01014 A1 20051110; YU 50402 A 20051128; ZA 200205879 B 20030929
DOCDB simple family (application)
IB 0100069 W 20010123; AP 2002002586 A 20010123; AR P010100285 A 20010123; AU 2542501 A 20010123; BG 10685002 A 20020620; BR 0107751 A 20010123; CA 2397961 A 20010123; CN 01804048 A 20010123; CO 01005268 A 20010124; CR 6706 A 20020717; CZ 20022475 A 20010123; DZ 013266 A 20010123; EA 200200643 A 20010123; EE P200200405 A 20010123; EP 01900591 A 20010123; GT 200100016 A 20010123; HN 2001000013 A 20010124; HU P0204141 A 20010123; IL 15054501 A 20010123; IS 6443 A 20020625; JP 2001561006 A 20010123; KR 20027009516 A 20020724; MA 26736 A 20020722; MX PA02007221 A 20010123; NO 20023527 A 20020724; OA 1200200213 A 20010123; PA 8510701 A 20010123; PE 2001000072 A 20010123; PL 35680201 A 20010123; SK 10632002 A 20010123; SV 2001000294 A 20010124; TN SN01014 A 20010124; YU P50402 A 20010123; ZA 200205879 A 20020723