EP 1254155 A1 20021106 - MOB-5/HMOB-5 AS A CANCER DIAGNOSTIC MARKER
Title (en)
MOB-5/HMOB-5 AS A CANCER DIAGNOSTIC MARKER
Title (de)
MOB-5/HMOB-5 ALS DIAGNOSTISCHES MARKIERUNGSMITTEL
Title (fr)
MOB-5/HMOB-5 UTILISE COMME MARQUEUR DIAGNOSTIC POUR LE CANCER
Publication
Application
Priority
- US 0102680 W 20010126
- US 17818500 P 20000126
Abstract (en)
[origin: WO0155170A1] The invention provides isolated nucleic acids comprising the nucleic acids set forth in the Sequence Listing as SEQ ID NO:1(corresponding to a cDNA encoding a rat Mob-5 protein), SEQ ID NO:3(corresponding to a cDNA encoding the cancer specific human Mob-5 protein homolog with an internal deletion of 53 amino acid residues, referred to as cMob-5.), SEQ ID NO:5(corresponding to a cDNA encoding a human Mob-5 protein), SEQ ID NO:7(corresponding to a nucleic acid encoding a rat Mob-5-AP fusion protein and SEQ ID NO:9(corresponding to a nucleic acid encoding a human Mob-5-AP fusion protein). The invention also provides purified polypeptides having the sequences set forth in the Sequence Listing as any of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8 and SEQ ID NO:10. This invention also relates to a method of detecting the presence of cancer in a patient comprising: a) contacting a sample from the patient with an antibody to Mob-5; and b) detecting the binding of the antibody with an antigen in the sample, wherein binding of antigen to the antibody indicates the presence of Mob-5 antigen in the sample and wherein Mob-5 antigen in the sample indicates the presence of cancer in the patient, thereby detecting the presence of cancer in the patient.
IPC 1-7
IPC 8 full level
C07K 16/30 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP)
C07K 16/30 (2013.01); G01N 33/5748 (2013.01); A61K 2039/505 (2013.01); G01N 2800/52 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0155170 A1 20010802; WO 0155170 A9 20021017; AU 3119201 A 20010807; EP 1254155 A1 20021106; EP 1254155 A4 20030618
DOCDB simple family (application)
US 0102680 W 20010126; AU 3119201 A 20010126; EP 01903364 A 20010126