Global Patent Index - EP 1254155 A1

EP 1254155 A1 2002-11-06 - MOB-5/HMOB-5 AS A CANCER DIAGNOSTIC MARKER

Title (en)

MOB-5/HMOB-5 AS A CANCER DIAGNOSTIC MARKER

Title (de)

MOB-5/HMOB-5 ALS DIAGNOSTISCHES MARKIERUNGSMITTEL

Title (fr)

MOB-5/HMOB-5 UTILISE COMME MARQUEUR DIAGNOSTIC POUR LE CANCER

Publication

EP 1254155 A1 (EN)

Application

EP 01903364 A

Priority

  • US 0102680 W
  • US 17818500 P

Abstract (en)

[origin: WO0155170A1] The invention provides isolated nucleic acids comprising the nucleic acids set forth in the Sequence Listing as SEQ ID NO:1(corresponding to a cDNA encoding a rat Mob-5 protein), SEQ ID NO:3(corresponding to a cDNA encoding the cancer specific human Mob-5 protein homolog with an internal deletion of 53 amino acid residues, referred to as cMob-5.), SEQ ID NO:5(corresponding to a cDNA encoding a human Mob-5 protein), SEQ ID NO:7(corresponding to a nucleic acid encoding a rat Mob-5-AP fusion protein and SEQ ID NO:9(corresponding to a nucleic acid encoding a human Mob-5-AP fusion protein). The invention also provides purified polypeptides having the sequences set forth in the Sequence Listing as any of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8 and SEQ ID NO:10. This invention also relates to a method of detecting the presence of cancer in a patient comprising: a) contacting a sample from the patient with an antibody to Mob-5; and b) detecting the binding of the antibody with an antigen in the sample, wherein binding of antigen to the antibody indicates the presence of Mob-5 antigen in the sample and wherein Mob-5 antigen in the sample indicates the presence of cancer in the patient, thereby detecting the presence of cancer in the patient.

IPC 1-7 (main, further and additional classification)

C07H 21/04; A61K 38/00; A61K 48/00; C07K 16/00; G01N 33/53

IPC 8 full level (invention and additional information)

C07K 16/30 (2006.01); G01N 33/574 (2006.01)

CPC (invention and additional information)

G01N 33/5748 (2013.01); C07K 16/30 (2013.01); A61K 2039/505 (2013.01); G01N 2800/52 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0155170 A1 20010802; WO 0155170 A9 20021017; AU 3119201 A 20010807; EP 1254155 A1 20021106; EP 1254155 A4 20030618

INPADOC legal status


2009-06-10 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20081213

2003-06-18 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20030506

2002-11-06 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020826

2002-11-06 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-06 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI